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Enasidenib in the treatment of relapsed/refractory acute myeloid leukemia: an evidence-based review of its place in therapy.
Introduction: Acute myeloid leukemia (AML) remains a disease with high mortality, especially for older patients and those with relapsed/refractory (R/R) disease. With recent advances in molecular testing, targeting particular leukemogenic mutations such as those occurring in isocitrate dehydrogenase (IDH) became possible. Enasidenib is a new small-molecule inhibitor of mutant isocitrate dehydrogenase-2 (IDH2). Aim: The objective of this article is to review the evidence for the use of enasidenib in R/R AML, as well as to outline future directions of enasidenib therapy. Evidence Review: Enasidenib was approved in August 2017, after a successful Phase I/II trial showing an overall response rate (ORR) of 40.3% in R/R disease, with 19.3% of patients achieving complete remission (CR). Enrollees in the trial were mostly older adults. The most prominent toxicities were hyperbilirubinemia and IDH-differentiation syndrome (IDH-DS), though the drug was generally well tolerated and the maximum tolerated dose was not reached. A Phase III trial is currently ongoing. Conclusion: Enasidenib provides a new therapeutic option for patients with R/R AML. Further studies are ongoing to ascertain its role in combination with other agents and newly diagnosed disease
Backhaul For Low-Altitude UAVs in Urban Environments
Unmanned Aerial Vehicles (UAVs) acting as access points in cellular networks
require wireless backhauls to the core network. In this paper we employ
stochastic geometry to carry out an analysis of the UAV backhaul performance
that can be achieved with a network of dedicated ground stations. We provide
analytical expressions for the probability of successfully establishing a
backhaul and the expected data rate over the backhaul link, given either an LTE
or a millimeter-wave backhaul. We demonstrate that increasing the density of
the ground station network gives diminishing returns on the performance of the
UAV backhaul, and that for an LTE backhaul the ground stations can benefit from
being colocated with an existing base station network
Coverage Analysis for Low-Altitude UAV Networks in Urban Environments
Wireless access points on unmanned aerial vehicles (UAVs) are being
considered for mobile service provisioning in commercial networks. To be able
to efficiently use these devices in cellular networks it is necessary to first
have a qualitative and quantitative understanding of how their design
parameters reflect on the service quality experienced by the end user. In this
paper we set up a scenario where a network of UAVs operating at a certain
height above ground provide wireless service within coverage areas shaped by
their directional antennas. We provide an analytical expression for the
coverage probability experienced by a typical user as a function of the UAV
parameters.Comment: Under Submissio
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