Improving procurement autonomous institutions

В современной России закупки как средство воздействия на экономику имеют большое значение, знания в области регулирования закупок, а также надлежаще право примирительная практика оказывает положительный эффект на реформирование законодательства. Предложения по совершенствованию законодательства, проверены на практике в и могут быть использованы в правоприменительной практике.In modern Russia procurement as a means of influencing the economy are important knowledge in the field of regulation of procurement, as well as the right to properly apologetic practice has a positive effect on the legislative reform. Proposals to improve legislation, tested in practice in Urfa and can be used in law enforcement

Workflow-Based Internet Platform for Mass Supercomputing

© 2018, Pleiades Publishing, Ltd. An experience of designing integrated hardware and software solutions for highperformance computing in solving modern geophysical problems on the basis of full-wave inversion is described. Problems of designingmass high-performance software systems intended for extensive use in industry are discussed

Effect of insolation variations on vegetations of the Eurasian subarctic during the Holocene

Variation of the insolation is one of the global factors which determine the Earth's climate. Multi-periodic variations of the insolation determine the cyclicity of the Earth's climate. The aim of the investigation is the estimation of the insolation variations influence on vegetations of the Urals and West Siberia subarctic during the Holocene. The calculation of insolation in the Eurasian Subarctic for the Holocene is carried out based on the solution La2004 for the long-period evolution of the Earth's orbit. We have estimated the insolation for the latitudes from 55° to 70° N. We have considered the mean daily and mean monthly insolation over 12 ka BP. We assess changes of the insolation in the Eurasian subarctic under the influence of such factor as the topography evolution. The surface topography was analyzed for the recent period (in the Urals and West Siberia) and the Pliocene epoch (in West Siberia). An assessment of the difference in the corresponding digital elevation models showed that the subsidence of the crust took place in West Siberia (the median value of the difference between the digital elevation models was 230.7 m above sea level). The intensity of erosion processes increased in a southerly direction. We have shown that an increase in the number of autumn's months with high insolation correlates with the taiga biome 4 thousand years ago to wider territories than 8 thousand years ago. © Published under licence by IOP Publishing Ltd.Russian Foundation for Basic Research, RFBR: 19-04-00966The study is supported by RFBR, research project no. 19-04-00966

Agglomerative effects in economic development (on the example of regions of Russia)

The article deals with agglomerative effects which can be used as the instrument of increase of economic activity and efficiency of development of certain territories. The mechanism of positive impact of agglomerative effects on territory development is shown. The sphere of high technologies as fundamental for territory development in modern conditions is considered. Major factors for formation of the hi-tech sphere in regions of Russia are revealed. Experience of some subjects of Russia on formation of the market of intellectual property and formation of city agglomerations, as key for ensuring economic development of regions of Russia is given. Examples of state (municipal) - private partnerships in economic development of region are reviewed, use of adaptive approach for its realization is offered

Estimation of specific energy capacity of flywheel-housing system in potential field

© 2014 D.V.Berezhnoi et al. The paper introduces basic methods of computational investigation for specific energy capacity of kinetic energy storages based on flywheel-housing scheme. In addition to the traditional estimation of energy capacity on the flywheel kinetic energy, we consider estimation of specific energy capacity of flywheel-housing system in potential field. We analyze the possibilities of the use of various structural materials in the manufacture of flywheel and its housing. Notice, that potential field in flywheel-housing system allows to increase the specific energy capacity of kinetic energy storage

Surface thermohardening by the fast-moving electric arch

© Published under licence by IOP Publishing Ltd.This paper describes the technology of modern engineering-plasma hardening steels and prospects of its application. It gives the opportunity to manage the process without using of cooling media, vacuum, special coatings to improve the absorptive capacity of hardened surfaces; the simplicity, the low cost, the maneuverability, a small size of the process equipment; a possibility of the automation and the robotization of technological process

Effect of propolis bioflavonoids on the antioxidant potential of ejaculate and on oxidative sperm DNA damage

The investigation was undertaken to assess the molecular mechanisms of antioxidant action of propolis bioflavonoids in pathospermia. It included the data of examining 75 infertile males and 36 fertile ones. The 3-month administration of the agent in a daily dose of 40 mg resulted in normalization of ejaculate parameters, a reduction in the levels of biomarkers for oxidative protein and sperm DNA damage, and recovery of the antioxidant status of seminal plasma.</em

Impact of dietary supplements based on L-carnitine on free-radical processes in model systems

Introduction. According to the results of numerous studies and meta-analyses, the effectiveness of male infertility therapy with micronutrients-antioxidants in various variants remains low, especially concerning the increase in live-birth rates and the incidence of clinical pregnancy. This may be due to both the empirical nature of such therapy with an imbalance of ejaculate redox systems, and an overdose of individual ingredients of antioxidant complexes.Purpose of the study. To evaluate the antioxidant activity of complex preparation based on L-carnitine for the treatment of male infertility in an experimental model system.Materials and methods. The dietary supplements «AndroDoz®» («Nizhfarm» JSC, Russian Federation) and «Proxeed® plus» (Sigma-Tau Pharmaceuticals Inc., Italy) were tested. The antioxidant properties of the preparations were determined in vitro by recording chemiluminescence in model systems generating reactive oxygen species using the «LKB-Wallac 1256 chemiluminometer» (Wallac Oy/PerkinElmer®, Finland). Chemiluminescence was evaluated by the light sum and the maximum amplitude of the glow, the antioxidant activity in the biological environment was studied when adding drugs to chicken yolk lipids similar to blood lipoprotein complexes.Results. The introduction of «AndroDoz®» and «Proxeed® plus» into the incubation medium in an amount comparable to the physiological level of L-carnitine in seminal plasma, inhibited the luminescence of the model system. At the same time, if «Proxeed® plus» almost completely inhibited the formation of radicals, then an equivalent dose of «AndroDoz®» reduced the intensity of chemiluminescence by 60%. Approximately in the same proportions, the preparations suppressed the intensity of lipid peroxidation processes in a model system with lipoprotein complexes similar to blood lipids, that is, the antioxidant activity was preserved in the biological environment. A decrease in the value of the chemiluminescence light sum was also found against the background of the use of these dietary supplements, which may indicate their protective effect on biological membranes, including subcellular structures of spermatozoa.Conclusion. The combined dietary supplements used in the study have a high antioxidant potential. The preparation «Proxeed® plus» can completely suppress the processes of lipoperoxidation with the possible development of a deficiency of free radicals that provide vital processes. The preparation «AndroDoz®» has a milder effect on free-radical phenomena probably due to a lower content of active ingredients and a balanced composition, which reduces the risk of complications in the form of an «antioxidant paradox» or reductive stress