Non-stationary discharge patterns in motor cortex under subthalamic nucleus deep brain stimulation

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) directly modulates the basal ganglia (BG), but how such stimulation impacts the cortex upstream is largely unknown. There is evidence of cortical activation in 6-hydroxydopamine (OHDA)-lesioned rodents and facilitation of motor evoked potentials in Parkinson's disease (PD) patients, but the impact of the DBS settings on the cortical activity in normal vs. Parkinsonian conditions is still debated. We use point process models to analyze non-stationary activation patterns and inter-neuronal dependencies in the motor and sensory cortices of two non-human primates during STN DBS. These features are enhanced after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which causes a consistent PD-like motor impairment, while high-frequency (HF) DBS (i.e., ≥100 Hz) strongly reduces the short-term patterns (period: 3–7 ms) both before and after MPTP treatment, and elicits a short-latency post-stimulus activation. Low-frequency DBS (i.e., ≤50 Hz), instead, has negligible effects on the non-stationary features. Finally, by using tools from the information theory [i.e., receiver operating characteristic (ROC) curve and information rate (IR)], we show that the predictive power of these models is dependent on the DBS settings, i.e., the probability of spiking of the cortical neurons (which is captured by the point process models) is significantly conditioned on the timely delivery of the DBS input. This dependency increases with the DBS frequency and is significantly larger for high- vs. low-frequency DBS. Overall, the selective suppression of non-stationary features and the increased modulation of the spike probability suggest that HF STN DBS enhances the neuronal activation in motor and sensory cortices, presumably because of reinforcement mechanisms, which perhaps involve the overlap between feedback antidromic and feed-forward orthodromic responses along the BG-thalamo-cortical loop

A numerical investigation of a piezoelectric surface acoustic wave interaction with a one-dimensional channel

We investigate the propagation of a piezoelectric surface acoustic wave (SAW) across a GaAs/Al$_X$Ga$_{1-X}$As heterostructure surface, on which there is fixed a metallic split-gate. Our method is based on a finite element formulation of the underlying equations of motion, and is performed in three-dimensions fully incorporating the geometry and material composition of the substrate and gates. We demonstrate attenuation of the SAW amplitude as a result of the presence of both mechanical and electrical gates on the surface. We show that the incorporation of a simple model for the screening by the two-dimensional electron gas (2DEG), results in a total electric potential modulation that suggests a mechanism for the capture and release of electrons by the SAW. Our simulations suggest the absence of any significant turbulence in the SAW motion which could hamper the operation of SAW based quantum devices of a more complex geometry.Comment: 8 pages, 8 figure

Off-shell effects in dilepton production from hot interacting mesons

The production of dielectrons in reactions involving a_1 mesons and pions is studied. We compare results obtained with different phenomenological Lagrangians that have been used in connection with hadronic matter and finite nuclei. We insist on the necessity for those interactions to satisfy known empirical properties of the strong interaction. Large off-shell effects in dielectron production are found and some consequences for the interpretation of heavy ion data are outlined. We also compare with results obtained using experimentally-extracted spectral functions.Comment: 14 pages, LaTeX2e, 2 figure

Percolation in invariant Poisson graphs with i.i.d. degrees

Let each point of a homogeneous Poisson process in R^d independently be equipped with a random number of stubs (half-edges) according to a given probability distribution mu on the positive integers. We consider translation-invariant schemes for perfectly matching the stubs to obtain a simple graph with degree distribution mu. Leaving aside degenerate cases, we prove that for any mu there exist schemes that give only finite components as well as schemes that give infinite components. For a particular matching scheme that is a natural extension of Gale-Shapley stable marriage, we give sufficient conditions on mu for the absence and presence of infinite components

The Distribution Of Chlorine And Iodine In Soil In The Vicinity Of Lead Mining And Smelting Operations, Bixby Area, S.E. Missouri, U.S.A.

Iodine and Cl are enriched in soils in the vicinity of the Magmont and Buick lead mines near Bixby, southeastern Missouri. The enrichments, up to 5.6 ppm I and 305 ppm Cl, are against regional background of 1.26 ppm I and 41 ppm Cl. The area of highest I and Cl is thought to reflect a zone of base metal sulphide mineralization occurring about 400 m below the surface. Iodine and Cl are also enriched in soils immediately adjacent to a tailings pond, hence these elements would appear to be leached from this source. A zone of enhanced I values (up to 2.65 ppm I) to the north of a lead smelter is superimposed on a much larger zone of lead enrichment (up to 12,000 ppm Pb) and is thought to represent I released from sulphide ores on smelting. © 1988

Properties of vector mesons at finite temperature -effective lagrangian approach-

The properties of $\rho$-mesons at finite temperature ($T$) are examined with an effective chiral lagrangian in which vector and axial-vector mesons are included as massive Yang-Mills fields of the chiral symmetry. It is shown that, at $T^2$ order, the effective mass is not changed but only the mixing effect in vector and axial-vector correlator appears.Comment: 13 pages (REVTeX), two figures

Synchrotron x-ray study of lattice vibrations in CdCr2O4

Using inelastic x-ray scattering we have investigated lattice vibrations in a geometric frustrated system CdCr2O4 that upon cooling undergoes a spin-Peierls phase transition at TN = 7.8 K from a cubic and paramagnetic to a tetragonal and Neel state. Phonon modes measured around Brillouin zone boundaries show energy shifts when the transition occurs. Our analysis shows that the shifting can be understood as the ordinary effects of the lowering of the crystal symmetry

Formalism for dilepton production via virtual photon bremsstrahlung in hadronic reactions

We derive a set of new formulas for various distributions in dilepton production via virtual photon bremsstrahlung from pseudoscalar mesons and unpolarized spin-one-half fermions. These formulas correspond to the leading and sub-leading terms in the Low-Burnett-Kroll expansion for real photon bremsstrahlung. The relation of our leading-term formulas to previous works is also shown. Existing formulas are examined in the light of Lorentz covariance and gauge invariance. Numerical comparison is made in a simple example, where an "exact" formula and real photon data exist. The results reveal large discrepancies among different bremsstrahlung formulas. Of all the leading-term bremsstrahlung formulas, the one derived in this work agrees best with the exact formula. The issues of M_T-scaling and event generators are also addressed.Comment: 37 pages, RevTeX, epsf.sty, 10 embedded figure

Dilepton-tagged jets in relativistic nucleus-nucleus collisions: A case study

We study the A+B -> l+ l- + jet +X process in nucleus-nucleus collisions at relativistic energies. The dilepton as well as the jet will pass through the matter produced in such collisions. The recoiling dilepton will carry information about the kinematical features of the jet, and will thus prove to be a very effective tool in isolating in-medium effects such as energy-loss and fragmentation function modifications. We estimate the contributions due to correlated charm and bottom decay and we identify a window where they are small as compared to pairs from the NLO Drell-Yan process.Comment: 7 pages, 9 figures Two figures modified, references adde

Re-evaluating the factor structure of the Tolerance of Ambiguity of Medical Students And Doctors (TAMSAD) scale in newly qualified doctors

This is the final version. Available on open access from MedEdPublish via the DOI in this recordData availability: Underlying data: Newcastle University: Questionnaire data files for study of interim Foundation Year 1 (FiY1) doctors transition to practice in 2000. https://doi.org/10.25405/data.ncl.2253709926. The project contains the following underlying data: - final phase 1 data for repository.csv - final phase 2 data for repository.csv Extended data: Newcastle University: Questionnaire data files for study of interim Foundation Year 1 (FiY1) doctors transition to practice in 2000. https://doi.org/10.25405/data.ncl.2253709926. The project contains the following extended data: - README.txt (brief description of the contents of all files) - Phase 1 questionnaire.pdf - Phase 2 questionnaire.pdf - questionnaire field key for repository.xlsx Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).Background Ambiguity and uncertainty are inherent within the practice of medicine. While theory suggests the construct may be multidimensional, scales such as the Tolerance of Ambiguity of Medical Students And Doctors (TAMSAD) act unidimensionally, at least in a local population. Therefore, the dimensionality of the Tolerance of Ambiguity (ToA) construct remains unclear. This study aims to explore the dimensionality of ToA in early postgraduate doctors using the TAMSAD scale in a UK national sample and consider the implications of this dimensionality for theory and practice. Methods We used data from 428 respondents in a national research project examining the experiences of newly qualified doctors in the UK (2020). We undertook an exploratory factor analysis (extracting one-factor to six-factor solutions) of the 29-item TAMSAD scale and compared findings to an existing integrative model of uncertainty tolerance. Results The analysis suggested that the ToA construct is multidimensional. The three-factor model and five-factor model provided clinically interpretable factors and had different merits. It appears that having an affinity for complexity is not simply the opposite of experiencing discomfort from uncertainty, and that a professional’s epistemological beliefs about the nature of medicine may influence their ToA. Conclusions These findings support an extension to a key integrative model of uncertainty tolerance, and support development of interventions to increase ToA in doctors. For example, through encouraging increased reflection on an individual’s own epistemological beliefs about medicine and the role of doctors. The potential impact of such interventions can be evaluated using scales such as the TAMSAD