Histograms of the lacunar volumes for the three different sites are shown.

<p>Histograms are normalized to the area under the total number of lacunae for each site. Bin size is set to 50 µm³. The transparent areas indicate the standard error for each site based on the individual samples.</p

In (A) a relative mass density distribution is shown.

<p>The peak at around −100 is due to the air outside the sample, and the broad peak at about 200 is due to the glue used to attach the sample that managed to travel up the sample. In (B) the after segmentation is shown, and the parameters derived from it are indicated.</p

Histograms of all jaw lacunae grouped in either BRONJ or healthy bone.

<p>The shaded areas correspond to the standard error based on the different samples. Histograms are normalized to the absolute amount of lacunae, bin size is 50 µm³. It should be noted that even though the histograms of the two groups look very similar, there are differences between the histograms of individual donors.</p

Mean and standard deviation of the investigated properties for the different anatomical sites and pathology are summarized.

<p>The * indicates that those properties are statistically significantly different between the BRONJ and control jaw.</p

Investigated differences with respect to anatomical sites, assessed by analyses of variance (ANOVA), followed by post hoc multiple comparison Bonferroni tests are summarized.

<p>Significant differences between groups are indicated by a horizontal bar. If the significance level was reached, the p-Value and the F-Value are reported.</p

Slides of a reconstructed volume corresponding to a control jaw specimen are shown in A (x-y-plane) and B (x-z-plane).

<p>The white dashed lines in A and B indicate where A is located in B and vice versa. C shows a minimum intensity projection, the projection range is 30 pixels (10.5 µm). D shows the lacunae mask corresponding to C, also in the form of an intensity projection (z-range = 30 pixels). Color bar in mass density of a.u.</p

Mean and standard deviation of the investigated morphometric properties of the segmented vessel-pores for the different anatomical sites and pathology are summarized.

<p>Ca.V: canal volume, BV: bone volume, Ca.S: canal surface.</p

Sample details such as age, gender, anatomical region, BP treatment and duration of the BP treatment are listed.

<p>‘Z’: intravenous administration of Zoledronate, ‘A’: oral administration of Alendronate, ‘n.k.’: not known.</p

The are shown for the three regions, with region 1, region 2, and region 3 being the top, the middle, and the lower sub-section of one specimen scanned, respectively.

<p>The are shown for the three regions, with region 1, region 2, and region 3 being the top, the middle, and the lower sub-section of one specimen scanned, respectively.</p

Volume renderings of two subsections originating from the jaw (A, B) and the femur (C, D. A and C show the lacunae and canals from a “top-down” perspective while B and D are shown from a “front-on” perspective.

<p>The volumes of the lacunae are color-coded in units of µm³.</p