14 research outputs found
Response to Methylphenidate in Children with Attention Deficit Hyperactivity Disorder and Manic Symptoms in the Multimodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder Titration Trial
Objective:
Recent reports raise concern that children with attention deficit hyperactivity disorder (ADHD) and
some manic symptoms may worsen with stimulant treatment. This study examines the response to
methylphenidate in such children.
Methods:
Data from children participating in the 1-month methylphenidate titration trial of the Multimodal
Treatment Study of Children with ADHD were reanalyzed by dividing the sample into children with and
without some manic symptoms. Two “mania proxies” were constructed using items from the Diagnostic
Interview Schedule for Children (DISC) or the Child Behavior Checklist (CBCL). Treatment response and
side effects are compared between participants with and without proxies.
Results:
Thirty-two (11%) and 29 (10%) participants fulfilled criteria for the CBCL mania proxy and DISC
mania proxy, respectively. Presence or absence of either proxy did not predict a greater or lesser response or
side effects.
Conclusion:
Findings suggest that children with ADHD and manic symptoms respond robustly to
methylphenidate during the first month of treatment and that these children are not more likely to have an
adverse response to methylphenidate. Further research is needed to explore how such children will respond
during long-term treatment. Clinicians should not a priori avoid stimulants in children with ADHD and some
manic symptoms
How to Handle a Hard-to-Handle Kid: A Parents' Guide to Understanding and Changing Problem Behaviors
DSM-IV-TR casebook and treatment guide for child mental health/ Edit.: Cathryn A. Galanter
xlii, p. 702; 24 c
DSM-IV-TR casebook and treatment guide for child mental health/ Edit.: Cathryn A. Galanter
xlii, p. 702; 24 c
DSM-IV-TR casebook and treatment guide for child mental health/ Edit.: Cathryn A. Galanter
xlii, p. 702; 24 c
DSM-IV-TR casebook and treatment guide for child mental health/ Edit.: Cathryn A. Galanter
xlii, p. 702.; 24 c