CP violation in 5D Split Fermions Scenario

We give a new configuration of split fermion positions in one extra dimension with two different Yukawa coupling strengths for up-type, $h_u$, and down-type, $h_d$, quarks at $\frac{h_u}{h_d}=36.0$. The new configurations can give enough CP violating (CPV) phase for accommodating all currently observed CPV processes. Therefore, a 5D standard model with split fermions is viable. In addition to the standard CKM phase, new CPV sources involving Kaluza-Klein(KK) gauge bosons coupling which arise from the fact that unitary rotation which transforms weak eigenstates into their mass eigenstates only holds for the zero modes which are the SM fields and not for the KK excitations. We have examined the physics of kaon, neutron, and $B/D$ mesons and found the most stringent bound on the size $R$ of the extra dimension comes from $|\epsilon_K|$. Moreover, it depends sensitively on the width, $\sigma$, of the Gaussian wavefunction in the extra dimension used to describe of the fermions. When $\sigma/R \ll 1$, the constraint will be lifted due to GIM suppression on the flavor changing neutral current(FCNC) and CPV couplings.Comment: 24 pages, 8 figure

Gravity duals of 2d supersymmetric gauge theories

We find new supergravity solutions generated by D5-branes wrapping a four-cycle and preserving four and two supersymmetries. We first consider the configuration in which the fivebranes wrap a four-cycle in a Calabi-Yau threefold, which preserves four supersymmetries and is a gravity dual to the Coulomb branch of two-dimensional gauge theories with N=(2,2) supersymmetry. We also study the case of fivebranes wrapping a co-associative four-cycle in a manifold of G_2-holonomy, which provides a gravity dual of N=(1,1) supersymmetric Yang-Mills theory in two dimensions. We also discuss the addition of unquenched fundamental matter fields to these backgrounds and find the corresponding gravity solutions with flavor brane sources.Comment: 34 pages + appendices; v2: minor improvement

Le retour des grands mammifères sauvages dans la région méditerranéenne française.

Cet article consacré au retour des grands mammifères sauvages dans la région méditerranéenne française, parle du passé des extinctions, de la pénurie à l'abondance des grands mammifères, de l'historique de l'évolution des ongulés (sanglier, chevreuil, cerf, mouflon, chamois et bouquetin), des évolutions probables, et des connaissances prévisibles

Maternal early pregnancy dietary glycemic index and load, fetal growth, and the risk of adverse birth outcomes

Purpose: Maternal hyperglycemia is associated with adverse birth outcomes. Maternal dietary glycemic index and load influence postprandial glucose concentrations. We examined the associations of maternal early pregnancy dietary glycemic index and load with fetal growth and risks of adverse birth outcomes. Methods: In a population-based cohort study of 3471 pregnant Dutch women, we assessed dietary glycemic index and load using a food frequency questionnaire at median 13.4 (95% range 10.6; 21.2) weeks gestation. We measured fetal growth in mid- and late-pregnancy by ultrasound and obtained birth outcomes from medical records. Results: Mean maternal early pregnancy dietary glycemic index and load were 57.7 (SD 3.3, 95% range 52.8; 63.5) and 155 (SD 47, 95% range 87; 243), respectively. Maternal early pregnancy dietary glycemic index was not associated with fetal growth parameters. A higher maternal early pregnancy dietary glycemic load was associated with a higher fetal abdominal circumference and estimated fetal weight in late-pregnancy (p values < 0.05), but not with mid-pregnancy or birth growth characteristics. A higher maternal early pregnancy dietary glycemic index was associated with a lower risk of a large-for-gestational-age infant (p value < 0.05). Maternal early pregnancy glycemic index and load were not associated with other adverse birth outcomes. Conclusion: Among pregnant women without an impaired glucose metabolism, a higher early pregnancy dietary glycemic load was associated with higher late-pregnancy fetal abdominal circumference and estimated fetal weight. No consistent associations of maternal dietary glycemic index and load with growth parameters in mid-pregnancy and at birth were present. A higher glycemic index was associated with a lower risk of a large-for-gestational-age infant

The proton spin sum rule chiral bag prediction, an update

We reevaluate a quark model prediction using the new QCD evolution function calculated to the 3 loop order and conclude that this model compares favorably with the new experimental results.Comment: 10 pages, 2 figures available by request, give fax numbe

On the geometry of string duals with backreacting flavors

Making use of generalized calibrated geometry and G-structures we put the problem of finding string-duals with smeared backreacting flavor branes in a more mathematical setting. This more formal treatment of the problem allows us to easily smear branes without good coordinate representations, establish constraints on the smearing form and identify a topological central charge in the SUSY algebra. After exhibiting our methods for a series of well known examples, we apply them to the problem of flavoring a supergravity-dual to a d=2+1 dimensional N=2 super Yang-Mills-like theory. We find new solutions to both the flavored and unflavored systems. Interpretating these turns out to be difficult.Comment: 38 pages - Typos corrected and references added - As published in JHE

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.

The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum could determine the particular vulnerability of this brain region to mutant huntingtin (mHtt). Here, we studied the striatal protein µ-crystallin (Crym). Crym is the NADPH-dependent p38 cytosolic T3-binding protein (p38CTBP), a key regulator of thyroid hormone (TH) T3 (3,5,3'-triiodo-l-thyronine) transportation. It has been also recently identified as the enzyme that reduces the sulfur-containing cyclic ketimines, which are potential neurotransmitters. Here, we confirm the preferential expression of the Crym protein in the rodent and macaque striatum. Crym expression was found to be higher in the macaque caudate than in the putamen. Expression of Crym was reduced in the BACHD and Knock-in 140CAG mouse models of HD before onset of striatal atrophy. We show that overexpression of Crym in striatal medium-size spiny neurons using a lentiviral-based strategy in mice is neuroprotective against the neurotoxicity of an N-terminal fragment of mHtt in vivo. Thus, reduction of Crym expression in HD could render striatal neurons more susceptible to mHtt suggesting that Crym may be a key determinant of the vulnerability of the striatum. In addition our work points to Crym as a potential molecular link between striatal degeneration and the THs deregulation reported in HD patients