Divergent Synthesis of C5‐Heteroatom Substituted Oxazoles

5‐Oxazoyl‐sulfamates have been profiled as versatile building blocks for modifications of oxazoles with various nucleophiles. The unified approach provides a diversification platform to directly access 5‐amino‐oxazoles, 5‐oxazolyl‐sulfides, and 5‐oxazoyl‐aryl ethers from a single precursor

Agglomeration and welfare: the core-periphery model in the light of Bentham, Kaldor, and Rawls

The objective of this paper is to apply different welfare approaches to the canonical model developed by Krugman, with the aim of comparing the only two possible market outcomes, i.e. agglomeration and dispersion. More precisely, we use the Pareto criterion, the compensation criteria put forward by Kaldor, as well as the utilitarian and Rawlsian welfare functions. No clear answer emerges for the following two reasons: (i) except for small range of transport cost values, there is indetermination when compensation schemes are used and (ii) the best outcome heavily depends on societal values regarding inequalities across individuals. In particular, our analysis cautions against the use of utilitarian welfare functions as a foundation for regional policy recommendations

Templated Total Synthesis of Cu(I)-Methanobactin OB3b

Methanobactin OB3b (Mbn-OB3b) is a unique natural product featuring two ene-thiolate-azlactone rings incorporated in a rigidified peptide backbone. The stunning affinity of this chalkophore for copper (Ka ≈ Cu(I) 10E34) makes it a prominent lead compound for Cu-transport, metabolism, and detoxification. Its exceptional structure poses particular challenges for biosynthesis and chemical manipulation. Here, we report the first total synthesis of Cu(I)-bounded methanobactin OB3b featuring as key transformations a cyclodehydration-thioacylation sequence, to generate the conjugated heterocyclic systems, and a copper-templated cyclization, to complete the caged structure of the sensitive chalkophore