MicroRNA regulation of CD8+ T cell responses.

MicroRNAs (miRNAs) are a class of short noncoding RNAs that play critical roles in the regulation of a broad range of biological processes. Like transcription factors, miRNAs exert their effects by modulating the expression of networks of genes that operate in common or convergent pathways. CD8+ T cells are critical agents of the adaptive immune system that provide protection from infection and cancer. Here, we review the important roles of miRNAs in the regulation of CD8+ T cell biology and provide perspectives on the broader emerging principles of miRNA function

Thrifty swimming with shear-thinning

Microscale propulsion is integral to numerous biomedical systems, for example biofilm formation and human reproduction, where the surrounding fluids comprise suspensions of polymers. These polymers endow the fluid with non-Newtonian rheological properties, such as shear-thinning and viscoelasticity. Thus, the complex dynamics of non-Newtonian fluids presents numerous modelling challenges, strongly motivating experimental study. Here, we demonstrate that failing to account for "out-of-plane" effects when analysing experimental data of undulatory swimming through a shear-thinning fluid results in a significant overestimate of fluid viscosity around the model swimmer C. elegans. This miscalculation of viscosity corresponds with an overestimate of the power the swimmer expends, a key biophysical quantity important for understanding the internal mechanics of the swimmer. As experimental flow tracking techniques improve, accurate experimental estimates of power consumption using this technique will arise in similar undulatory systems, such as the planar beating of human sperm through cervical mucus, will be required to probe the interaction between internal power generation, fluid rheology, and the resulting waveform

Undulatory swimming in fluids with polymer networks

The motility behavior of the nematode Caenorhabditis elegans in polymeric solutions of varying concentrations is systematically investigated in experiments using tracking and velocimetry methods. As the polymer concentration is increased, the solution undergoes a transition from the semi-dilute to the concentrated regime, where these rod-like polymers entangle, align, and form networks. Remarkably, we find an enhancement in the nematode's swimming speed of approximately 65% in concentrated solutions compared to semi-dilute solutions. Using velocimetry methods, we show that the undulatory swimming motion of the nematode induces an anisotropic mechanical response in the fluid. This anisotropy, which arises from the fluid micro-structure, is responsible for the observed increase in swimming speed.Comment: Published 1 November 2013 in Europhysics Letter

A New Pseudopolymorph of Hexakis-(4-cynaophenyl)benzene

The title compound (systematic name: benzene-4,4′,4′′,4′′′,-4′′′′,4′′′′′-hexaylhexabenzonitrile dichloromethane disolvate), C48H24N6•2CH2Cl2, crystallizes as an inclusion compound during the slow diffusion of methanol into a solution of hexakis(4-cyanophenyl)benzene in CH2Cl2. The hexakis(4- cyanophenyl)benzene molecule lies on an axis of twofold rotation in the space group Pbcn. Weak C—H•••N interactions between hexakis(4-cyanophenyl)benzene molecules define an open network with space for including guests. The resulting structure is a new pseudopolymorph of hexakis-(4-cyanophenyl)benzene. The eight known pseudopolymorphs have few shared architectural features, in part because none of the intermolecular interactions that are present plays a dominant role or forces neighboring molecules to assume particular relative orientations

Group classification of (1+1)-Dimensional Schr\"odinger Equations with Potentials and Power Nonlinearities

We perform the complete group classification in the class of nonlinear Schr\"odinger equations of the form $i\psi_t+\psi_{xx}+|\psi|^\gamma\psi+V(t,x)\psi=0$ where $V$ is an arbitrary complex-valued potential depending on $t$ and $x,$ $\gamma$ is a real non-zero constant. We construct all the possible inequivalent potentials for which these equations have non-trivial Lie symmetries using a combination of algebraic and compatibility methods. The proposed approach can be applied to solving group classification problems for a number of important classes of differential equations arising in mathematical physics.Comment: 10 page

X,Y,Z-Waves: Extended Structures in Nonlinear Lattices

Motivated by recent experimental and theoretical results on optical X-waves, we propose a new type of waveforms in 2D and 3D discrete media -- multi-legged extended nonlinear structures (ENS), built as arrays of lattice solitons (tiles or stones, in the 2D and 3D cases, respectively). First, we study the stability of the tiles and stones analytically, and then extend them numerically to complete ENS forms for both 2D and 3D lattices. The predicted patterns are relevant to a variety of physical settings, such as Bose-Einstein condensates in deep optical lattices, lattices built of microresonators, photorefractive crystals with optically induced lattices (in the 2D case) and others.Comment: 4 pages, 4 figure

Alien Registration- Gagnon, Joseph D. (Bar Harbor, Hancock County)

https://digitalmaine.com/alien_docs/19328/thumbnail.jp