INTEGRATED COMMUNICATION AND TRANSPORTATION EFFICIENCY – SOME STUDY CASES

A critical factor in search, rescue or criminal investigation is time – specifically, the time needed to complete a big number of tasks that occur in any emergency. A critical asset in assisting disaster relief teams and public safety personnel in their mission to save lives and defend property loss is the access to resources data – location of personnel, emergency service resources, streets, buildings. The ability to locate resources, on foot or in vehicles, in relation to the local transportation infrastructure in a specific geographic area need to be considered in a new way of managing emergency situations. The TETRA based systems integrated with a wide range of mapping, tracking, alarming and resource-allocations applications used in conjunction with a dispatcher tool allows operational teams to manage a large ground, water and air-based emergency teams using voice and text communications.Public Safety, Maritime Rescue Co-ordination Centre (MRCC), AIS, RIS, Air Traffic Management (ATM), Incident and Operative Scenarios, Operability, Efficiency

PROGNOSIS OF MONTHLY UNEMPLOYMENT RATE IN THE EUROPEAN UNION THROUGH METHODS BASED ON ECONOMETRIC MODELS

In this paper we propose the prognosis of the unemployment rate in the European Union through the Box-Jenkins method and the TRAMO/SEATS method as well as the detection of the method which proves to provide the best results. The monthly unemployment rate in the European Union is affected by seasonal variations of deterministic and stochastic nature. The prognosis through the Box-Jenkins nature supposes the separate consideration of seasonal variations, according to their specific nature. The stochastic seasonal variations are modelled and prognosticated simultaneously with the other components of the time series, based on the generating stochastic process. The prognosis of the monthly unemployment rate in the European Union through the TRAMO/SEATS methods is done by aggregating the individual prognoses of the components of the time series, obtained according to the stochastic processes models that generate them.seasonal variations, stochastic process, moving average, prognosis, performance indicators of the prognosis

Confidence Indicators Analysis in the Context of Romanian and European Economy

AbstractThe aim of this paper is to analyze the hypothesis according to which industrial confidence indicator is affected by the reference series from the economic sector represented by the industrial production index and at the same time bears the stamp of other national, European and world macroeconomic indicators. We analyse the correlation and causality between the industrial confidence indicator and macroeconomic indicators. For the identified factors, we elaborate models of multivariate classical and discrete regression that explain the formation of confidence in industry. Pursuant to the results obtained, the industrial confidence indicator of Romania is more strongly influenced by the reference series at EU (27) level, as compared to the series registered at national level

THE WORLD OIL MARKET – STATISTICAL ANALYSIS

For some countries the oil is the main source of income, while for others it represents the main raw material for energetic needs. Thus, the oil price has major influence on their economies and it is important for them that it stabilizes at a level profitworld oil market, comparative analysis, OPEC, G8

A New Perspective on Reusing Semantic Resources

Well trained linguists manage to capture semantic behavior of words in various annotated corpora. Using them as training data, semantic relations can be discovered by intelligent systems using supervised machine learning techniques. What if we have short deadlines and limited human and financial possibilities that prevent us from building such a valuable training corpus for our own language? If such a corpus already exists for any other language, we could make use of this treasure and reproduce it for the language we need. This paper proposes an import method, which transfers semantic annotation (which could be semantic roles, named entity, sentiments, etc.) from an annotated resource to another language, using comparable texts. The case of semantic role annotation transfer from English to Romanian is discussed

Advanced Technology in the Psychomotric Tenacity Study with Implications in Performance Sport

AbstractThe tenacity, regarding perseverance and persistence, is a very important psycho-motric quality for all sports, but mostly for combat sports. Being a quality from the volitive sphere, the measure can only be proven post factum. The indirect, correlative testing offers true information, using a tenacity index based on the solicitation of the excito- inhibitory processes of the palm flexor effort (amplitude, period, consistence, visual control of the oscillation etc.). Our research points out the fact that the tenacity index in significantly higher (300.14) for the right-handed athletes than for the left-handed ones or ambidextrous ones (259.62), at the significance threshold F < F critic (1,16<1,76)

A Biodistribution and Toxicity Study of Cobalt Dichloride–NAcetyl Cysteine (C4) as an Implantable MRI Marker for Prostate Cancer Treatment

Purpose—C4, a cobalt dichloride–N-acetyl cysteine complex, is being developed as a positivesignal magnetic resonance imaging (MRI) marker to localize implanted radioactive seeds in prostate brachytherapy. We evaluated the toxicity and biodistribution of C4 in rats with the goal of simulating systemic effects of potential leakage from C4 MRI markers within the prostate. Methods—9 μl doses (equivalent to leakage from 120 markers in a human) of control (0.9% sodium chloride), 1% (proposed for clinical use) and 10% C4 solution were injected into the prostates of male Sprague-Dawley rats via laparotomy. Organ toxicity and cobalt disposition in plasma, tissues, feces and urine were evaluated. Results—No C4-related morbidity or mortality was observed in the biodistribution arm (60 rats). Biodistribution was measurable following 10% C4 injection: cobalt was cleared rapidly from periprostatic tissue; mean concentrations in prostate were 163 μg/g and 268 μg/g at 5 and 30 minutes but were undetectable by 60 minutes. Expected dual renal-hepatic elimination was observed with % injected dose recovered in tissues of 39.0 ±5.6% (liver) \u3e 11.8 ±6.5% (prostate) \u3e 5.3 ±0.9% (kidney) with low plasma concentrations detected up to 1 hr (1.40 μg/ml at 5–60 minutes). Excretion in urine was 13.1 ±4.6 % with 3.1 ±0.54 % recovered in feces by 24 hours. In the toxicity arm, three animals died in the control group and 1 each in the 1% and 10% groups from surgical or anesthesia-related complications; all others survived to scheduled termination at 14 days. No C4-related adverse clinical signs or organ toxicity was observed. Conclusion—C4-related toxicity was not observed at exposures at least 10-fold that proposed for human use. This data demonstrating lack of systemic toxicity with dual routes of elimination in the event of in-situ rupture suggests C4 warrants further investigation as an MRI marker for prostate brachytherapy

Intratumoral Biosynthesis of Gold Nanoclusters by Pancreatic Cancer to Overcome Delivery Barriers to Radiosensitization

Nanoparticle delivery to solid tumors is a prime challenge in nanomedicine. Here, we approach this challenge through the lens of biogeochemistry, the field that studies the flow of chemical elements within ecosystems as manipulated by living cellular organisms and their environments. We leverage biogeochemistry concepts related to gold cycling against pancreatic cancer, considering mammalian organisms as drivers for gold nanoparticle biosynthesis. Sequestration of gold nanoparticles within tumors has been demonstrated as an effective strategy to enhance radiotherapy; however, the desmoplasia of pancreatic cancer impedes nanoparticle delivery. Our strategy overcomes this barrier by applying an atomic-scale agent, ionic gold, for intratumoral gold nanoparticle biosynthesis. Our comprehensive studies showed the cancer-specific synthesis of gold nanoparticles from externally delivered gold ions in vitro and in a murine pancreatic cancer model in vivo; a substantial colocalization of gold nanoparticles (GNPs) with cancer cell nuclei in vitro and in vivo; a strong radiosensitization effect by the intracellularly synthesized GNPs; a uniform distribution of in situ synthesized GNPs throughout the tumor volume; a nearly 40-day total suppression of tumor growth in animal models of pancreatic cancer treated with a combination of gold ions and radiation that was also associated with a significantly higher median survival versus radiation alone (235 vs 102 days, respectively)

Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker CoCl2-N-Acetylcysteine in Rats

C4 (cobalt dichloride-N-acetylcysteine [1% CoCl 2 :2% NAC]) is a novel magnetic resonance imaging contrast marker that facilitates visualization of implanted radioactive seeds in cancer brachytherapy. We evaluated the toxicity of C4. Rats were assigned to control (0% CoCl 2 :NAC), low-dose (0.1% CoCl 2 :2% NAC), reference-dose (C4), and high-dose (10% CoCl 2 :2% NAC) groups. Agent was injected into the left quadriceps femoris muscle of the rats. Endpoints were organ and body weights, hematology, and serum chemistry and histopathologic changes of tissues at 48 hours and 28 and 63 days after dosing. Student\u27s t tests were used. No abnormalities in clinical signs, terminal body and organ weights, or hematologic and serum chemistry were noted, and no gross or histopathologic lesions of systemic tissue toxicity were found in any treatment group at any time point studied. At the site of injection, concentration-dependent acute responses were observed in all treatment groups at 48 hours after dosing and were recovered by 28 days. No myofiber degeneration or necrosis was observed at 28 or 63 days in any group. In conclusion, a single intramuscular dose of C4 produced no acute or chronic systemic toxicity or inflammation in rats, suggesting that C4 may be toxicologically safe for clinical use in cancer brachytherapy

Functional consequence of the MET-T1010I polymorphism in breast cancer.

Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2% of patients with metastatic breast cancer. Expression of MET-T1010I in the context of mammary epithelium increases colony formation, cell migration and invasion in-vitro and tumor growth and invasion in-vivo. A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials