Clinical significance of roms, oxy, shp and hmgb‐1 in canine leishmaniosis

This study aimed to investigate the role of oxidative stress parameters (ROMs, OXY, SHp), the Oxidative Stress index (OSi), and High Mobility Group Box-1 protein (HMGB-1) in canine leishmaniosis (CanL). For this study, thirty dogs, naturally infected with Leishmania spp. (Leishmania Group, LEISH) and ten healthy adult dogs (control group, CTR) were included. The diagnosis of CanL was performed by a cytological examination of lymph nodes, real time polymerase chain reaction on biological tissues (lymph nodes and whole blood), and an immunofluorescence antibody test (IFAT) for the detection of anti-Leishmania antibodies associated with clinical signs such as dermatitis, lymphadenopathy, onychogryphosis, weight loss, cachexia, lameness, conjunctivitis, epistaxis, and hepatosplenomegaly. The HMGB-1 and oxidative stress parameters of the LEISH Group were compared with the values recorded in the CTR group (Mann Whitney Test, p < 0.05). Spearman rank correlation was applied to evaluate the correlation between the HMGB-1, oxidative stress biomarkers, hematological and biochemical parameters in the LEISH Group. Results showed statistically significant higher values of SHp in the LEISH Group. Specific correlation between the ROMs and the number of red blood cells, and between HGMB-1 and SHp were recorded. These preliminary data may suggest the potential role of oxidative stress in the pathogenesis of CanL. Further studies are undoubtedly required to evaluate the direct correlation between inflammation parameters with the different stages of CanL. Similarly, further research should investigate the role of ROMs in the onset of anemia

PRENOLIN project. Results of the validation phase at sendai site

One of the objectives of the PRENOLIN project is the assessment of uncertainties associated with non-linear simulation of 1D site effects. An international benchmark is underway to test several numerical codes, including various non-linear soil constitutive models, to compute the non-linear seismic site response. The preliminary verification phase (i.e. comparison between numerical codes on simple, idealistic cases) is now followed by the validation phase, which compares predictions of such numerical estimations with actual strong motion data recorded from well-known sites. The benchmark presently involves 21 teams and 21 different non-linear computations. Extensive site characterization was performed at three sites of the Japanese KiK-net and PARI networks. This paper focuses on SENDAI site. The first results indicate that a careful analysis of the data for the lab measurement is required. The linear site response is overestimated while the non-linear effects are underestimated in the first iteration. According to these observations, a first set of recommendations for defining the non-linear soil parameters from lab measurements is proposed. PRENOLIN is part of two larger projects: SINAPS@, funded by the ANR (French National Research Agency) and SIGMA, funded by a consortium of nuclear operators (EDF, CEA, AREVA, ENL)

Novel Key Ingredients in Urinary Tract Health-The Role of D-mannose, Chondroitin Sulphate, Hyaluronic Acid, and N-acetylcysteine in Urinary Tract Infections (Uroial PLUS®)

: Urinary tract infections represent a common and significant health concern worldwide. The high rate of recurrence and the increasing antibiotic resistance of uropathogens are further worsening the current scenario. Nevertheless, novel key ingredients such as D-mannose, chondroitin sulphate, hyaluronic acid, and N-acetylcysteine could represent an important alternative or adjuvant to the prevention and treatment strategies of urinary tract infections. Several studies have indeed evaluated the efficacy and the potential use of these compounds in urinary tract health. In this review, we aimed to summarize the characteristics, the role, and the application of the previously reported compounds, alone and in combination, in urinary tract health, focusing on their potential role in urinary tract infections

Natural History of Non-Small-Cell Lung Cancer with Bone Metastases

We conducted a large, multicenter, retrospective survey aimed to explore the impact of tumor bone involvement in Non-Small Cell Lung Cancer.Data on clinical-pathology, skeletal outcomes and bone-directed therapies for 661 deceased patients with evidence of bone metastasis were collected and statistically analyzed. Bone metastases were evident at diagnosis in 57.5% of patients. In the remaining cases median time to bone metastases appearance was 9 months. Biphosphonates were administered in 59.6% of patients. Skeletal-related events were experienced by 57.7% of patients; the most common was the need for radiotherapy. Median time to first skeletal-related event was 6 months. Median survival after bone metastases diagnosis was 9.5 months and after the first skeletal-related event was 7 months. We created a score based on four factors used to predict the overall survival from the diagnosis of bone metastases: age &gt;65 years, non-adenocarcinoma histology, ECOG Performance Status &gt;2, concomitant presence of visceral metastases at the bone metastases diagnosis. The presence of more than two of these factors is associated with a worse prognosis.This study demonstrates that patients affected by Non-Small Cell Lung Cancer with bone metastases represent a heterogeneous population in terms of risk of skeletal events and survival

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p &lt; 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p &lt; 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p &lt; 0.0001) or urgent (20.4% vs. 38.5%; p &lt; 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p &lt; 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

Effect of Base Conditions in One-Dimensional Numerical Simulation of Seismic Site Response: A Technical Note for Best Practice

The effects induced by the choice of numerical base conditions for evaluating local seismic response are investigated in this technical note, aiming to provide guidelines for professional applications. A numerical modelling of the seismic site response is presented, assuming a one-dimensional scheme. At first, with reference to the case of a homogeneous soil layer overlying a half-space, two different types of numerical base conditions, named rigid and elastic, were adopted to analyse the seismic site response. Then, geological setting, physical and mechanical properties were selected from Italian case studies. In detail, the following stratigraphic successions were considered: shallow layer 1 (shear wave velocity, VS, equal to 400 m/s), layer 2 (VS equal to 600 m/s) and layer 3 (VS equal to 800 m/s). In addition, real signals were retrieved from the web site of the Italian accelerometric strong motion network. Rigid and elastic base conditions were adopted to estimate the ground motion modifications of the reference signals. The results are presented in terms of amplification factors (i.e., ratio of integral quantities referred to free-field and reference response spectra) and are compared between the adopted numerical models

Criticità relative al calcolo dell’amplificazione sismica

L’obiettivo della presentazione è quello di sollecitare l’attenzione di coloro che lavorano con strumenti di calcolo (in questo caso è stato scelto STRATA di Kottke et alii, 2013) su alcune criticità delle scelte in fase di elaborazione dei dati e sul fatto che non esiste un approccio univoco per i diversi assetti geologici e geotecnici

The Influence of Input Motion Scaling Strategies on Nonlinear Ground Response Analyses of Soft Soil Deposits

A key issue for the estimation of ground shaking is the proper selection of input motions at the seismic bedrock. At the same time, the effect of the input motion scaling strategy on structural response is typically studied disregarding the presence of the soil deposit. In this work, different soft soil deposits are selected by varying the shear wave velocity profiles and the depth to the seismic bedrock, modelling the soil behaviour through a nonlinear constitutive model implemented into a fully coupled FE code. Seven input motions are retrieved for several selection strategies in conjunction with two seismic intensity levels. Hence, more than 300 one-dimensional ground response analyses are performed. The results of the analysed cases, which are presented in terms of spectral response at ground surface and amplification factors, indicate that: (i) the use of an advanced elasto-plastic soil constitutive model accounts for nonlinear ground response effects, including higher site amplification in the mid-period range and deamplification of the peak ground accelerations; (ii) the different scaling strategies lead to comparable mean values of the amplification factors, and (iii) the variability of the amplification factors is significantly reduced when the scaling strategy seeks the compatibility with the target spectrum over a specified period range. The research will aid the prediction of local seismic site response over large areas, particularly in the absence of the fundamental period of a structure and facilitate its use in general recommendation for quantifying and reducing uncertainty

Metaverso Architettura e Territorio. L’esperienza del SicilyLab2022 a Gioiosa Marea

The project works on a physical and a virtual dimension. The question designers are asking is how to use digital technology to break down barriers, be they physical, psychological or cultural. What is imagined is a virtual twin of the cave, an entity that can exist in the Metaverse – hence the nickname Meta-Tone – and be accessible in a new way. The project involves the creation of an immersive virtual environment that reconstructs the cave in a simplified way and in which the user is able to navigate through Oculus technology. Virtual reality will be used to attract the user and make him curious about the underground cavity

Criticità relative al calcolo dell’amplificazione sismica: le inversioni di velocità

L’obiettivo della presentazione è quello di sollecitare l’attenzione di coloro che lavorano con strumenti di calcolo su alcune criticità delle scelte in fase di elaborazione dei dati e sul fatto che non esiste una «ricetta» giusta e adatta per tutti gli assetti geologici e geotecnici. In pratica non si offrono soluzioni, ma piuttosto si presentano problemi su cui riflettere