28 research outputs found
The effect of various immunosuppressive agents on mouse peritoneal macrophages and on the in vitro phagocytosis of Escherichia coli O4:K3:H5 and degradation of 125I-labelled HSA-antibody complexes by these cells.
Large doses of hydrocortisone, cyclophosphamide, and methotrexate injected subcutaneously, and whole-body irradiation (500 rads) caused a reduction in the number of peritoneal cells (PE cells) obtained after intraperitoneal injection of the treated mice with proteose-peptone. The same dose of cyclophosphamide and irradiation induced morphological changes in PE macrophages. There were more giant cells in the peritoneal exudates from treated mice as compared to control mice. 'Pharmacological' and larger doses of hydrocortisone, methotrexate and azathioprine or anti-lymphocyte globulin had no effect on the in vitro phagocytic capacity of proteose-peptone-stimulated mouse PE macrophages. This also applied to doses of up to 50 mg/kg of cyclophosphamide. In contrast, whole-body irradiation (500 rad) and 100 mg/kg of cyclophosphamide decreased the phagocytic capacity of mouse macrophages in vitro and reduced the ability of PE cells to degrade 125I-labelled HSA-antibody complexes in vitro. The greatest effect was noted 4-5 days after whole-body irradiation or four to five subcutaneous injections of cyclophosphamide
R-CHOEP-14 improves overall survival in young high-risk patients with diffuse large B-cell lymphoma compared with R-CHOP-14. A population-based investigation from the Danish Lymphoma Group
Effects of Immunomodulators on Ecto-5'-Nucleotidase Activity on Blood Mononuclear Cells In Vitro
Selected characteristics of pathogenic and nonpathogenic strains of Bacteroides gingivalis
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JET multi-pellet injection experiments
The multiple injection of deuterium pellets into JET plasmas under various scenarios for limiter and X-point discharges with currents up to 5 MA with pure ohmic, neutral beam and RF heating has been undertaken in a collaborative effort between JET and an USDOE team under the umbrella of the EURATOM-USDOE (US Department of Energy) Fusion Agreement on Pellet Injection using an ORNL built 3-barrel, repetitive multi-pellet launcher. The best plasma performance with pellet injection and additional heating so far has been obtained by injecting early into 3 MA, 3.1 T pulses while centrally depositing the pellet mass, with N{sub eo} initially well in excess of 10{sup 20} m{sup {minus}3}. Subsequent central heating of this dense and clean core by ion cyclotron resonance heating (ICRH) with H and {sup 3}He minorities in the 10 MW range yields T{sub eo} up to 12 keV and T{sub io} up to more than 10 keV, while n{sub eo} is decreasing (within up to 1.5s) decaying to 0.6 {times} 10{sup 20} m{sup {minus}3}, suggesting an enhanced central energy confinement in limiter discharges with only modestly improved global L-mode confinement. In this plasma core electron pressures of more than 1 bar with gradients in the order of 4 bar*m{sup {minus}1} have been reached with the total pressure approaching ballooning stability limits. The resulting total neutron rate from D-D reactions of up to 4.5*10{sup 15} s{sup {minus}1} so far increases strongly with RF power and can exceed that of similar non-enhanced shots by factors of 3 to 5. n{sub D}(O)*T{sub i}(O)*{tau}{sub E}(a) products in the range of 1 to 2*10{sup 20} m{sup {minus}3} keVs are obtained but combined power with neutral beams (up to 28 MW total), generally degrades the performance though leading to higher neutron rates of up to 7*10{sup 15} s{sup {minus}1}. 10 refs., 8 figs