Formulation and Investigation of Eroding Hydrophilic Matrix Systems

On the basis of this study the following can be con cluded: •There is a correlation between the wetting properti es of powder mixtures and the erosion of inert comprimates. •Factors which increase wetting time are relevant for temperature elevation during the formulation of this system. The effect of operational factors can be predicted from the results of such preformulation studies. •The composition applied was appropriate for the incorporation of LA. It can be processed into the granulating fluid (up to concentration of 15%). The presence of LA in the granulating fluid altered significantly neither the particle size distribution, nor the mechanical properties of the granules. The shape of the tablets constantly changed during the dissolution, the main alteration could be seen after 4 h. Erosion and change in shape were very similar for each of the samples. •The pH-decreasing effect of the tablets was influenced by the concentration of LA applied in the granulating fluid. Erosion is the main parameter responsible for the liberation of LA from this system in the first partof dissolution. This phenomenon increased the possibility of detachment of LA from the insoluble carrier. When the concentration of LA reached a given level, the more readily liberating sites were saturated. In the second stage of dissolution the relevance of erosion was lower and the slower process became more important. Finally, it can be stated that a controlled release intravaginal matrix tablet can be formulated from the matrix former HPMC and the carrier MCC to ensure a long-acting preparation containing LA. In addition, there was no sign of matrix destruction caused by the LA as a strong acid

Exploring the Impact of Technology Use with Cosmetic Science Guest-Speakers: A Qualitative Study

Improvements in current classroom technology such as video conferencing have allowed geographically-distant guest-speakers to participate in teaching. However, is time and effort that faculty may spend coordinating guest-speakers helpful for their students’ learning? Relevance is key to motivation and learning, and therefore, it would seem that professionals who can share industry applications and their experiences should help promote relevance. During the core application-based cosmetic science coursework in an undergraduate cosmetic science and formulation design degree at the University of Toledo, multiple industry experts come in as guest-speakers. The majority of them join remotely via a real-time video conferencing tool. The purpose of this study was to both explore the impact of guest-speakers on these students’ learning, as well as to understand how guest-speakers might also value these experiences. Twenty-two students and sixteen guest-speakers participated. Using a qualitative approach, authors used an inductive thematic analysis of transcripts from focus-groups of students and interviews of guest-speakers. Twenty-one codes were identified, and five themes were constructed for both the student and guest-speaker groups. Themes from both groups were integrated and distilled into an essence related to teaching and learning. Our results indicated that students greatly appreciated the relevance from guest-speakers to augment their introductory/foundational instruction from faculty. From guest-speakers’ perspectives, teaching students was formative towards developing informed future coworkers for the cosmetic industry. Technology enabled much of this. Overall, we believe that professional, experienced guest-speakers can make an impact on students. We hope that other higher education institutions might consider technology to foster use of guest-speakers within their programs.   Article Type: Original Researc

Introducing an Undergraduate Degree of Cosmetic Science and Formulation Design within a College of Pharmacy

As a unique and versatile undergraduate degree program, a Bachelor of Science in Pharmaceutical Sciences (BSPS) is offered by a number of colleges/schools of pharmacy. These provide a bachelor's degree concentrated in pharmaceutical sciences, and can be a non-Doctor of Pharmacy option, possibly before progressing to graduate degree studies. Recently implemented at the University of Toledo College of Pharmacy and Pharmaceutical Sciences (UTCPPS), one such BSPS major is Cosmetic Science and Formulation Design. This new undergraduate major was created to serve the needs of the cosmetic and personal care industry, with a great need identified for well-trained new professionals with basic knowledge in the sciences and business. This Cosmetic Science and Formulation Design major was added to four other BSPS majors at UTCPPS. Introduced in 2013, this major is the only functioning undergraduate degree in Cosmetic Science and Formulation Design in the United States. Preliminary job placement data provides promising evidence that this undergraduate major has helped graduates launch a career in the cosmetic and personal care, or pharmaceutical industries. Based on our experience from the past three years, we believe that this cosmetic science major has been worth its resource investment. We hope others designing new undergraduate pharmaceutical sciences programs might integrate advice from this experience into their impending programs.   Type: Idea Pape

Alkenones as a promising green alternative for waxes in cosmetics and personal care products

© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Cosmetics 5 (2018): 34, doi:10.3390/cosmetics5020034.The move toward green, sustainable, natural products has been growing in the cosmetic and personal care industry. Ingredients derived from marine organisms and algae are present in many cosmetic products. In this study, a new green ingredient, a wax (i.e., long-chain alkenones) derived from Isochyrsis sp., was evaluated as an alternative for cosmetic waxes. First, the melting point was determined (71.1–77.4 °C), then the alkenones’ thickening capability in five emollients was evaluated and compared to microcrystalline wax and ozokerite. Alkenones were compatible with three emollients and thickened the emollients similarly to the other waxes. Then, lipsticks and lip balms were formulated with and without alkenones. All products remained stable at room temperature for 10 weeks. Lipstick formulated with alkenones was the most resistant to high temperature. Finally, alkenones were compared to three cosmetic thickening waxes in creams. Viscosity, rheology, and stability of the creams were evaluated. All creams had a gel-like behavior. Both viscosity and storage modulus increased in the same order: cream with alkenones < cetyl alcohol < stearic acid < glyceryl monostearate. Overall, alkenones’ performance was comparable to the other three waxes. Alkenones can thus offer a potential green choice as a new cosmetic structuring agent.This research was funded by the Washington Research Foundation and a private donor from friends of the Woods Hole Oceanographic Institution, grant number N-126478

formulasi dan teknologi kosmetik

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Introducing an Undergraduate Degree of Cosmetic Science and Formulation Design within a College of Pharmacy

As a unique and versatile undergraduate degree program, a Bachelor of Science in Pharmaceutical Sciences (BSPS) is offered by a number of colleges/schools of pharmacy. These provide a bachelor's degree concentrated in pharmaceutical sciences, and can be a non-Doctor of Pharmacy option, possibly before progressing to graduate degree studies. Recently implemented at the University of Toledo College of Pharmacy and Pharmaceutical Sciences (UTCPPS), one such BSPS major is Cosmetic Science and Formulation Design. This new undergraduate major was created to serve the needs of the cosmetic and personal care industry, with a great need identified for well-trained new professionals with basic knowledge in the sciences and business. This Cosmetic Science and Formulation Design major was added to four other BSPS majors at UTCPPS. Introduced in 2013, this major is the only functioning undergraduate degree in Cosmetic Science and Formulation Design in the United States. Preliminary job placement data provides promising evidence that this undergraduate major has helped graduates launch a career in the cosmetic and personal care, or pharmaceutical industries. Based on our experience from the past three years, we believe that this cosmetic science major has been worth its resource investment. We hope others designing new undergraduate pharmaceutical sciences programs might integrate advice from this experience into their impending programs.   Type: Idea Pape

Evaluation of alkenones, a renewably sourced, plant-derived wax as a structuring agent for lipsticks

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Huynh, A., Maktabi, B., Reddy, C. M., O'Neil, G. W., Chandler, M., & Baki, G. Evaluation of alkenones, a renewably sourced, plant-derived wax as a structuring agent for lipsticks. International Journal of Cosmetic Science, (2020), doi:10.1111/ics.12597.OBJECTIVE Waxes are used as structuring agents in lipsticks. There are a variety of waxes combined in a single lipstick to provide good stability, pleasant texture and good pay‐off. Due to a significant growth for natural, green and sustainable products, there is a constant search for alternatives to animal‐derived and petroleum‐derived ingredients. In this study, a green, non‐animalderived wax, namely long‐chain ketones (referred to as alkenones), sourced from marine microalgae was formulated into lipsticks and evaluated as a structuring agent. METHODS Alkenones were used as a substitute for microcrystalline wax, ozokerite and candelilla wax, typical structuring agents. In total, 384 lipsticks were formulated: L1 (control, no alkenones), L2 (alkenones as a substitute for ozokerite), L3 (alkenones as a substitute for microcrystalline wax) and L4 (alkenones as a substitute for candelilla wax). Products were tested for hardness (bending force), stiffness, firmness (needle penetration), pay‐off (using a texture analyser and a consumer panel), friction, melting point and stability for 12 weeks at 25 and 45°C. RESULTS Alkenones influenced each characteristic evaluated. In general, lipsticks with alkenones (L2‐L4) became softer and easier to bend compared to the control (L1). In terms of firmness, lipsticks were similar to the control, except for L4, which was significantly (P < 0.05) firmer. The effect on pay‐off was not consistent. L2 and L3 had higher pay‐off to skin and fabric than L1. In addition, L4 had the lowest amount transferred, but it still had the highest colour intensity on skin. Alkenones influenced friction (glide) positively; the average friction decreased for L2‐L4. The lowest friction (i.e. best glide) was shown in L4. Melting point of the lipsticks was lower when alkenones were present. Overall, L4, containing 7% of 4 alkenones in combination with microcrystalline wax, ozokerite and carnauba wax, was found to have the most desirable attributes, including ease of bending, high level of firmness, low pay‐off in terms of amount, high colour intensity on skin and low friction (i.e. better glide). Consumers preferred L4 the most overall. CONCLUSION Results of this study indicate that alkenones offer a sustainable, non‐animal and non‐petroleum‐derived choice as a structuring agent for lipsticks.The authors would like to thank Texture Technologies for the technical assistance provided during this project. This research was funded by the Washington Research Foundation and a private donor from friends of the Woods Hole Oceanographic Institution, grant number N‐127244