Different response to GABAa or H3 antagonists suggest the existence of distinct subpopulations amonghistaminergic neurons.

International audienc

Different response to GABAa or H3 antagonists suggest the existence of distinct subpopulations amonghistaminergic neurons.

International audienc

Generazione ed analisi di un modello tridimensionale dell'Isola di Salina (Arcipelago delle Isole Eolie) ottenuto da un rilievo aereofotogrammetrico ed estratto mediante tecniche digitali.

Nell\u2019ambito del rilievo aerofotogrammetrico dell\u2019isola di Salina (isole Eolie) \ue8 stato generato un modello digitale tridimensionale e la relativa ortofoto. E\u2019 stata effettuata un\u2019analisi specifica sulle prestazioni per la generazione automatica di modelli digitali del terreno (DTM \u2013 Digital Terrain Model) mediante l\u2019utilizzo del software Socet Set v. 5.3: sono stati estratti modelli, con differenti dimensioni del passo di griglia, valutando il corrispondente parametro di correlazione e le differenze tra ciascun DTM estratto automaticamente e quello di riferimento, ottenuto in seguito alle operazioni di editing manuale; i prodotti automatici sono stati inoltre confrontati e validati utilizzando un dataset di punti rilevati mediante la metodologia GPS in modalit\ue0 cinematic

Early impoverished environment delays the maturation of cerebral cortex

Abstract The influence of exposure to impoverished environments on brain development is unexplored since most studies investigated how environmental impoverishment affects adult brain. To shed light on the impact of early impoverishment on developmental trajectories of the nervous system, we developed a protocol of environmental impoverishment in which dams and pups lived from birth in a condition of reduced sensory-motor stimulation. Focusing on visual system, we measured two indexes of functional development, that is visual acuity, assessed by using Visual Evoked Potentials (VEPs), and VEP latency. In addition, we assessed in the visual cortex levels of Insulin-Like Growth Factor 1 (IGF-1) and myelin maturation, together with the expression of the GABA biosynthetic enzyme GAD67. We found that early impoverishment strongly delays visual acuity and VEP latency development. These functional changes were accompanied by a significant reduction of IGF-1 protein and GAD67 expression, as well as by delayed myelination of nerve fibers, in the visual cortex of impoverished pups. Thus, exposure to impoverished living conditions causes a significant alteration of developmental trajectories leading to a prominent delay of brain maturation. These results underscore the significance of adequate levels of environmental stimulation for the maturation of central nervous system

Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals

Environmental enrichment (EE) has a remarkable impact on brain development. Continuous exposure to EE from birth determines a significant acceleration of visual system maturation both at retinal and cortical levels. A pre-weaning enriched experience is sufficient to trigger the accelerated maturation of the visual system, suggesting that factors affected by EE during the first days of life might prime visual circuits towards a faster development. The search for such factors is crucial not only to gain a better understanding of the molecular hierarchy of brain development but also to identify molecular pathways amenable to be targeted to correct atypical brain developmental trajectories. Here, we showed that IGF-1 levels are increased in the visual cortex of EE rats as early as P6 and this is a crucial event for setting in motion the developmental program induced by EE. Early intracerebroventricular (i.c.v.) infusion of IGF-1 in standard rats was sufficient to mimic the action of EE on visual acuity development, whereas blocking IGF-1 signaling by i.c.v. injections of the IGF-1 receptor antagonist JB1 prevented the deployment of EE effects. Early IGF-1 decreased the ratio between the expression of NKCC1 and KCC2 cation/chloride transporters, and the reversal potential for GABAAR-driven Cl- currents (E-cl) was shifted toward more negative potentials, indicating that IGF-1 is a crucial factor in accelerating the maturation of GABAergic neurotransmission and promoting the developmental switch of GABA polarity from excitation to inhibition. In addition, early IGF-1 promoted a later occurring increase in its own expression, suggesting a priming effect of early IGF-1 in driving post-weaning cortical maturation. (C) 2016 Elsevier Ltd. All rights reserved

Functional heterogeneity of histaminergic neurons suggest interesting applications of GSK189254, a novel H3receptor antagonist

International audienc

Vertical Test Results on ESS Medium and High Beta Elliptical Cavity Prototypes Equipped with Helium Tank

International audienceThe ESS elliptical superconducting Linac consists of two types of 704.42 MHz cavities, medium and high beta, to accelerate the beam from 216 MeV (spoke cavity Linac) up to the final energy at 2 GeV. The last Linac optimization, called Optimus+, has been carried out taking into account the limitations of SRF cavity performance (field emission). The medium and high-beta parts of the Linac are composed of 36 and 84 elliptical cavities, with geometrical beta values of 0.67 and 0.86 respectively. This work presents the latest vertical test results on ESS medium and high beta elliptical cavity prototypes equipped with helium tank. We describe the cavity preparation procedure from buffer chemical polishing to vertical test

Vertical Test Results on ESS Medium Beta Elliptical Cavity Prototype

International audienceThe ESS elliptical superconducting Linac consists of two types of 704.42 MHz cavities, medium and high beta, to accelerate the beam from 216 MeV (spoke cavity Linac) up to the final energy at 2 GeV. The last Linac optimization, called Optimus+ [1], has been carried out taking into account the limitations of SRF cavity performance (field emission). The medium and high-beta parts of the Linac are composed of 36 and 84 elliptical cavities, with geometrical beta values of 0.67 and 0.86 respectively. This work presents the latest vertical test results on ESS medium beta elliptical cavity prototypes. We describe the cavity preparation procedure from buffer chemical polishing to vertical test. Finally magnetic probes (Fluxgate) were installed on the cavity to determine magnetic field background during vertical test. The latest vertical test results showed that our cavity design performance are beyond requirements

ESS MEDIUM BETA CAVITY PROTOTYPES MANUFACTURING

The ESS elliptical superconducting Linac consists of two types of 704.42 MHz cavities, medium and high beta, to accelerate the beam from 216 MeV (spoke cavity Linac) up to the final energy at 2 GeV. The last Linac optimization, called Optimus+, has been carried out taking into account the limitations of SRF cavity performance (field emission). The medium and high-beta parts of the Linac are composed of 36 and 84 elliptical cavities, with geometrical beta values of 0.67 and 0.86 respectively. We describe here the procedures and numerical analysis leading from half-cells to a complete medium cavity assembly, which take into account not only the frequency of the fundamental accelerating mode but also the higher order modes near the machine line. The half-cell selection process to form dumb bells will be described, as well as the reshaping and trimming procedure