Description of the 3 cases of antidepressant-induced liver injury.

<p>Description of the 3 cases of antidepressant-induced liver injury.</p

Evolution of liver function tests in the 3 cases of antidepressant-induced liver injury.

<p>Evolution of liver function tests in the 3 cases of antidepressant-induced liver injury.</p

Characteristics of patients with normal and abnormal LFT.

<p>Characteristics of patients with normal and abnormal LFT.</p

Quantification of plasma parameters and liver glycogen.

<p>Several parameters were quantified in plasma <b>(A)</b> Triglycerides, <b>(B)</b> Free fatty acid, <b>(C)</b> HDL, <b>(D)</b> Alkaline phosphatase (ALP)<b>. (E)</b> Liver glycogen in mice after 12 weeks of diet. Normal diet: ND; ND with fructose: ND/F; high fat diet: HFD; and HFD with fructose: HFD/F. Data represent the mean±SEM of 8 mice (Mann-Whitney, *: p<0.05, **: p<0.01).</p

Dysbiosis induced by HFD and fructose diets after 16 weeks of diet.

<p>Analysis of gut bacterial communities by 16S rDNA analysis in feces from mice fed with different diets. <b>(A)</b> PCA representation of microbiota profile. Each point corresponds to a community from a single mouse fed with different diet. <b>(B)</b> Percentages of <i>Enterobacteria</i>. <b>(C)</b> Percentages of <i>Bacteroides/Prevotella</i><b>(D)</b> Percentages of Mouse intestinal Bacteria. <b>(E)</b> Percentages of <i>Erysipelotrichi</i>. <b>(F)</b> Quantification of liver bacterial DNA. Data represent the mean±SEM of 8 animals (Mann-Whitney, *: p<0.05, **: p<0.01, ***p < 0.001).</p

Quantification of inflammation and KC phenotype after 16 weeks of diet.

<p>Hepatic mRNA level of genes involved in inflammation and in KC phenotype. mRNA levels were normalized to GAPDH expression and fold inductions were calculated. <b>(A)</b> TNFα, IL6. <b>(B)</b> F4/80, CD68, CCL2 and CCR2. <b>(C)</b> NOS2, Arginase and MRC1. Normal diet: ND; ND with fructose: ND/F; high fat diet: HFD; and HFD with fructose: HFD/F. Data represent the mean±SEM of 8 mice (Mann-Whitney, *: p<0.05, **: p<0.01, ***p < 0.001).</p

Follow-up of mice after 4, 8, 12 and 16 weeks period of feeding with ND, ND/F, HFD and HFD/F diets.

<p>Mice were fed with normal diet (ND), ND with fructose (ND/F), high fat diet (HFD) and HFD with fructose (HFD/F) diets during 4, 8, 12 and 16 weeks. <b>(A)</b> Evolution of mice weight. <b>(B)</b> Representative histograms of the area under the curve of the oral glucose tolerance test after 8 weeks of diet or <b>(D)</b> at 16 weeks of diet. (<b>C</b>) Curves of glycemia after an oral glucose tolerance test at 8 weeks of diet or (<b>E</b>) at 16 weeks of diet. <b>(F)</b> Caloric intake. Data represent the mean±SEM of 8 mice, *: p<0.05, **: p<0.01, ***p < 0.001.</p

Analysis of hepatic phenotype and fat mass after 16 weeks of diet.

<p><b>(A)</b> Histological examination of liver tissue section stained with Hematoxylin-eosin (scale 50um). <b>(B)</b> Hepatic triglyceride content. <b>(C)</b> Fat mass of epididymal adipose tissue amount. <b>(D)</b> Liver / weight ratio. <b>(E)</b> Plasma ALT level. <b>(F)</b> Plasma AST level. Normal diet: ND; ND with fructose: ND/F; high fat diet: HFD; and HFD with fructose: HFD/F. Data represent the mean±SEM of 8 mice, *: p<0.05, **: p<0.01, ***p < 0.001.</p

Predictive values of the <i>SS2 score</i> for the presence of sarcopenia one year after sleeve gastrectomy.

<p>Predictive values of the <i>SS2 score</i> for the presence of sarcopenia one year after sleeve gastrectomy.</p

Univariate analysis of baseline (before surgery) and follow-up (one year after surgery) parameters according to the presence of sarcopenia one year after sleeve gastrectomy.

<p>Univariate analysis of baseline (before surgery) and follow-up (one year after surgery) parameters according to the presence of sarcopenia one year after sleeve gastrectomy.</p