28 research outputs found
A role for surgery in primary pancreatic B-cell lymphoma: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Diaphragm Myoplasty in the Prevention of Complications after Surgery of Hydatid Disease of the Liver
A Global Assessment of the Inflammatory Response Elicited Upon Open Abdominal Aortic Aneurysm Repair
The inflammatory response during elective open infrarenal abdominal
aortic aneurysm repair and its impact on outcome is investigated. Twenty
high-risk patients were enrolled, and blood samples were obtained at 8
perioperative time points. Endotoxin, cytokines (tumor necrosis
factor-alpha and interleukin-1 beta, and interleukin-6), CD11b)
expression, and nitric oxide were measured. Peak endotoxin levels
occurred within 30 minutes of reperfusion and were higher among patients
developing complications. Interleukin-6 levels increased during
reperfusion, reaching a peak on the first postoperative day.
Interleukin-6 increase correlated with aortic clamp time and morbidity
CD11b expression increased 30 minutes after reperfusion, and this effect
was greater among patients who developed complications. Endotoxin may be
important in the pathogenesis of multiple organ dysfunction syndrome.
Activated neutrophils may have a central role in tissue injury after
reperfusion. Intraoperative CD11b upregulation may be an early marker
for postoperative complications after infrarenal abdominal aortic
aneurysm repair
Laparoscopic cholecystectomy after open cholecystostomy for gallbladder empyema: A case report
The case of a patient with gallbladder empyema initially drained through
a minilaparotomy procedure under local anesthesia with a tube
cholecystostomy is reported in this paper. Eight weeks later, the
patient underwent an elective interval laparoscopic cholecystectomy. At
laparoscopy, the gallbladder and the cholecystostomy tube were dissected
free from the abdominal wall and the greater omentum, which was attached
to the gallbladder. The tube was removed from the gallbladder fundus,
and the operation was completed laparoscopically without any major
problems
Primary liposarcoma of esophagus: A case report
Liposarcoma is the most common soft tissue sarcoma in adult life while
esophageal liposarcoma is an extremely rare tumor. In the world
literature, only 14 cases of esophageal liposarcomas have been
described. We report a 72-year old male patient who was urgently
admitted to our hospital for acute epigastric pain with a burning
retrosternal sensation, persistent nausea, vomiting and dysphagia.
Barium swallow, upper gastrointestinal (GI) endoscopy, esophageal
manometry and CT scan, failed to accurately diagnose the lesion. After
surgical resection of an esophageal polypoid tumor, the histological
examination revealed a well-differentiated grade I liposarcoma.
Diagnostic and therapeutic tools were discussed and the results of
literature were reviewed. (C) 2006 The WJG Press. All rights reserved
Abscesses of the spleen: Report of three cases
Abscess of the spleen is a rare discovery, with about 600 cases in the international literature so far. Although it may have various causes, it is most usually associated with trauma and infections of the spleen. The latter are more common in the presence of a different primary site of infection, especially endocarditis or in cases of ischemic infarcts that are secondarily infected. Moreover, immunosuppression is a major risk factor. Clinical examination usually reveals a combination of fever, left-upper-quadrant abdominal pain and vomiting. Laboratory findings are not constant. Imaging is a necessary tool for establishing the diagnosis, with a choice between ultrasound and computed tomography. Treatment includes conservative measures, and surgical intervention. In children and in cases of solitary abscesses with a thick wall, percutaneous catheter drainage may be attempted. Otherwise, splenectomy is the preferred approach in most centers. Here, we present three cases of splenic abscess. In all three, splenectomy was performed, followed by rapid clinical improvement. These cases emphasize that current understanding of spleen abscess etiology is still limited, and a study for additional risk factors may be necessary
Comparison of Fibrate, Ezetimibe, Low- and High-Dose Statin Therapy for the Dyslipidemia of the Metabolic Syndrome in a Mouse Model
Background and Aim: The treatment-of-choice for the optimal management
of the dyslipidemia of the metabolic syndrome (MetS) is not clearly
defined. We compared the efficacy of 4 drug regimes for the management
of this dyslipidemia in a mouse model. Materials and Methods: A total of
60 C57B16 mice comprised the study group. The first 10 received standard
mouse food for the whole experiment (control group). The remaining 50
mice received atherogenic diet for 14 weeks until the development of the
MetS. The mice were then divided into 5 groups: the 1st group continued
receiving atherogenic diet, while the other 4 groups received
atherogenic diet plus ezetimibe (10 mg/kg per day), fenofibrate (100
mg/kg per day), low-dose atorvastatin (10 mg/kg per day), or high-dose
(40 mg/kg per day) atorvastatin, respectively, for another 8 weeks.
Results: High-dose atorvastatin treatment achieved the best lipid
profile compared with low-dose atorvastatin, ezetimibe, and fibrate
therapy. The lipid profile of mice receiving atherogenic diet plus
high-dose atorvastatin treatment was similar with mice on regular chow.
Conclusions: High-dose atorvastatin treatment resulted in optimization
of the lipid profile in the presence of a high-fat atherogenic diet in a
mouse model. Our results suggest that high-dose atorvastatin treatment
may be the optimal treatment option for the dyslipidemia associated with
MetS. Nevertheless, verification of these results in humans is required
before any definite conclusions can be drawn