MNWS and ZSDS scores and CO levels of the three phenotypic clusters (C1, C2, C3) identified by two-step cluster analysis.

<p>MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale; SD, standard deviation.</p

Haplotype association tests on C3 phenotypic cluster in GLM and HapScore tests.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^a<i>p_model = 0.018</i>; GLM, general linear model.</p

Linkage disequilibrium map of the seven investigated SNPs.

<p>1 = rs4522666, 2 = rs6090378, 3 = rs3787138; 4 = rs1044396; 5 = rs3787140, 6 = rs2093107, 7 = rs755203.</p

Two-step cluster analysis of three phenotypic variables resulted in three significantly different clusters.

<p>Mean scores are represented as percentages of possible maximum points for each measurements. MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale.</p

Descriptive characteristics of the study population.

<p>FTND, Fagerström Test for Nicotine Dependence; MNWS, Minnesota Nicotine Withdrawal Scale; COPD, chronic obstructive pulmonary disorder; ZSDS, Zung Self-Rating Depression Scale; SD, standard deviation; MDD, major depressive disorder.</p

Frequencies of different haplotypes in phenotypic clusters.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^achi-square test indicated a significantly higher frequency of GCC haplotype in C3 compared to non-C3 clusters.</p

Results of risk analysis of haplotype carrying in different phenotypic clusters.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. OR, odds ratio.</p

Functional annotation analysis demonstrates that differentially expressed probe sets represent true biological difference between control and depressed suicide subject groups.

<p>Comparison of functional annotation analysis of differentially expressed probe sets generated at different <i>p</i> and FC cut-offs and randomly generated probe sets lists of the same size. Note the shift of the experimental curve to the right.</p

Summary of GO cluster analysis results for the lists of all differentially expressed genes.

<p>Enrichment score is a –Log10 of a geometric mean of individual <i>p</i> reported for individual GO terms within cluster. Only the top two clusters that exceed enrichment score cut-off of 2 (corresponds to geometric mean of <i>p</i> = 0.01) are listed. The listed terms that are present in cluster are the most representative of the main themes of all GO terms included in cluster.</p

Summary of GO cluster analysis results for the lists of differentially expressed genes with known direct relationships.

<p>Enrichment score is a –Log10 of a geometric mean of individual <i>p</i> reported for individual GO terms within cluster. Only top 5 clusters that exceed enrichment score cut-off of 2 (corresponds to geometric mean of <i>p</i> = 0.01) are listed. The listed terms present in cluster are the most representative of the main themes of all GO terms included in cluster.</p