Tailormade Drug Delivery System: A Novel Trio Concept of 3DP+ Hydrogel+ SLA

Hydrogels possess three-dimensional polymeric network structure and equipped for retaining extensive measure of water or organic fluids. This quality makes them as exceptional candidate for the simulation of extra cellular matrixes. For this the three dimensional printing (3DP) has evolved as the technique for the formation of the digital models. The 3DP is capable for processing the prescriptions and the therapeutic gadgets. One of the technique known as stereolithographic (SLA) printing has shown promising results in formulating the hydrogel based system for fabrication. The SLA acts by cross connecting the saps to shape the polymer matrices. Due to water captured in the gels it is conceivable to create the pre- wetted, medicate hydrogels and gadgets. The 3DP helps in formation of tailor made drug delivery system as per needs of patients. Many of Bioinks has been tried up for the hydrogel formation such as collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose etc. Keywords: 3D Printing, Hydrogel, Steriolithograph

An Overview: Preparation Characterization and Applications of Nanoparticles

For the past few decades, there has been a major investigate intrigues among the zone of medicate conveyance utilizing particulate conveyance frame works as carriers for the limited and expansive particles. Particulate frameworks like nanoparticles are utilizing as a physical approach to alter and move forward the pharmacological medicine and pharmacodynamics properties of various forms of sedate atoms. Nanoparticles area unit characterized as a particles with a breadth littler than 100nm, area unit increasingly utilize in many applications, count medicate framework and to pass organ obstructions like the blood brain barrier. Nano crystals and alternative nanoparticles are obtaining a parcel of thought for potential utilize in medicine, and medicine sedate revelation. The use of engineering science and prescription drugs and additional significantly sedate connivance is ready to unfold quickly. Right away various substances area unit at a lower place examination for sedate provides. Keywords: Nanoparticles, Types, Method of Preparation, Evaluation, Applications

Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents

Non-steroidal anti-inflammatory drugs (NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal (GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity