Alcohol, coagulation and fibrinolysis

Despite the solid evidence for thrombosis playing a key role in coronary heart disease (CHD) mortality, identifying specific haemostatic risk factors for CHD has been difficult except for fibrinogen. Excessive alcohol consumption clearly affects platelet function. Moderate alcohol consumption may affect several haemostatic factors, including fibrinogen concentration, platelet aggregability and the fibrinolytic factors tissue-type plasminogen activator and plasminogen activator inhibitor. These changes support the hypothesis that moderate alcohol beneficially affects the haemostatic balance in a way that decreases the risk of CHD mortality

Effects of processing conditions on glucosinolates in cruciferous vegetables.

Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological active compounds. Some compounds, for example isothiocyanates, show an anticarcinogenic action by inducing phase II biotransformation enzyme activity (Jongen, Proc. Nutr. Soc. 1996; 55: 433-446). Processing of brassica vegetables influences glucosinolate degradation and therefore the biological activity. We investigate the effects of processing conditions on glucosinolates and their breakdown products. Besides measurement of concentrations also the biological activity of these compounds will be analysed

Effects of processing conditions on glucosinolates in cruciferous vegetables.

Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological active compounds. Some compounds, for example isothiocyanates, show an anticarcinogenic action by inducing phase II biotransformation enzyme activity (Jongen, Proc. Nutr. Soc. 1996; 55: 433-446). Processing of brassica vegetables influences glucosinolate degradation and therefore the biological activity. We investigate the effects of processing conditions on glucosinolates and their breakdown products. Besides measurement of concentrations also the biological activity of these compounds will be analysed