16 research outputs found
Environmental and Health Effects of Benzene Exposure among Egyptian Taxi Drivers
Objectives. To study environmental exposure to benzene as well as hematological effects of benzene exposure in taxi drivers. Background. Exposure to benzene has been associated with adverse health effects, including haematopoietic disorders. Methods. A retrospective cohort study was carried out from the beginning of April 2017, through the end of June 2018, on 280 taxi drivers (the exposed group) and 120 unexposed matched individuals (controls). The tools included a predesigned self-administered questionnaire which contained questions about personal data (e.g., age, educational level, and smoking) and exposure data (e.g., duration and nature of exposure). Investigations involved complete blood count. Environmental studies for light-chain aromatic hydrocarbons (BTEX components: benzene, toluene, ethylbenzene, and xylene) were done. Results. Mean values (ppm) of ambient concentrations of benzene, toluene, ethylbenzene, and xylene (0.81 ± 0.42, 26.69 ± 0.54, 29.36 ± 2.35, and 25.11 ± 2.06, respectively) in the stations were higher than international permissible levels (P<0.001). On studying the clinical manifestations during the last two weeks, the prevalence of pallor, dizziness, headache, waist and back pain, fatigue, dry throat, and discomfort was significantly higher in taxi drivers (27.1%, 24.3%, 21.4%, 28.6%, 45.7%, 24.3%, and 25.7%, respectively) than among the controls (6.7%, 4.2%, 6.7%, 10%, 10%, 6.7%, 6.7%, and 9.2%, respectively). For chronic diseases, hypertension was the most prevalent chronic disease among the drivers (17.1%) than the controls (5.8%) (P=0.002). Regarding self-assessment of health status, 20.0% of taxi drivers reported poor health while 31.4% reported very good health (P<0.001). MCH (pg), TLC (×103/μl), and platelets (×103/μl) were significantly lower among taxi drivers (26.33 ± 2.31, 6.55 ± 1.38, and 189.07 ± 53.25, respectively) (P=0.005, <0.001, and <0.001 respectively). Conclusion. Abnormal hematological findings among taxi drivers were found on exposure to benzene. Health of taxi drivers is generally affected. Setting a clinic for periodic checkup and health education for taxi drivers is highly recommended
Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents
Background: There is a paucity of research that tracks changes in liver and kidney function among pesticide applicators. The aim of the current study was to investigate the role of repeated seasonal exposure to the organophosphorus pesticide, chlorpyrifos, on serum measures of liver and kidney function. Methods: Pesticide exposure was assessed by measuring the urinary concentrations of 3,5,6-trichloro-2 pyridinol (TCPy), a specific biomarker for chlorpyrifos. Chlorpyrifos exposure and 8 serum markers of liver and kidney function were measured at 15 timepoints over 3 years prior to, during, and following the end of seasonal pesticide application among adolescent applicators and non-applicators from 4 field stations in Menoufia, Egypt. Results: Urinary TCPy levels showed increases during the application cycles and recovery at the end of each application season. Altered serum markers of liver and kidney function were associated with chlorpyrifos exposure, with some markers recovering 3 months after the end of exposure each year, while other measures demonstrated progressive increase up to 300% the baseline levels at the end of 3 years. Conclusion: The study demonstrated that frequent assessment of liver and kidney function is a sound practice to evaluate cellular injury following chronic repeated occupational and environmental exposure to chlorpyrifos
Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41 (95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function
Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt
<div><p>Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds. Participants in both cohorts completed three neurobehavioral tests, health and exposure questionnaires, and medical and neurological screening examinations. In addition, blood samples were collected to measure butyryl cholinesterase (BChE) activity. Pesticide applicators in both cohorts reported more neurological symptoms and signs than non-applicators, particularly among participants in the 2005 cohort (OR ranged from 1.18 to 15.3). Except for one test (Trail Making B), there were no significant differences between either applicators or non-applicators of both cohorts on the neurobehavioral outcome measures (p > 0.05). The 2005 cohort showed greater inhibition of serum BChE activity than the 2009 cohort (p < 0.05). In addition, participants with depressed BChE activity showed more symptoms and signs than others without BChE depression (p < 0.05). Our study is the first to examine the consistency of health outcomes associated with pesticide exposure across two cohorts tested at different times from the same geographical region in rural Egypt. This similar pattern of findings across the two cohorts provides strong evidence of the health impact of exposure of adolescents to pesticides.</p></div
Median and interquantile range (IQR) of neurological symptoms and signs of the two cohorts according to BChE activity (in each cohort, depression in BChE activity was determined relative to normal ranges from the methods used).
<p>Median and interquantile range (IQR) of neurological symptoms and signs of the two cohorts according to BChE activity (in each cohort, depression in BChE activity was determined relative to normal ranges from the methods used).</p
Comparison of the neurological symptoms and signs between job categories in each cohort (OR and CI), and homogeneity evaluation of the comparisons across the two cohorts (X<sup>2</sup>, p-value) and the significance of the Mantel-Haenszel common odds ratio (M-H OR (95% CI).
<p>Comparison of the neurological symptoms and signs between job categories in each cohort (OR and CI), and homogeneity evaluation of the comparisons across the two cohorts (X<sup>2</sup>, p-value) and the significance of the Mantel-Haenszel common odds ratio (M-H OR (95% CI).</p
Differences in neurobehavioral performance between applicators and non-applicators of both cohorts.
<p>Differences in neurobehavioral performance between applicators and non-applicators of both cohorts.</p
Neurobehavioral functions assessed and the tests administered for both cohorts (2005 and 2009).
<p>Neurobehavioral functions assessed and the tests administered for both cohorts (2005 and 2009).</p
Correlation between Trail making test (A & B) and butyryl cholinesterase (BChE) levels in participants from the 2005 cohort.
<p>Correlation between Trail making test (A & B) and butyryl cholinesterase (BChE) levels in participants from the 2005 cohort.</p
Percent of participants with depressed BChE activity relative to the normal ranges in 2005 and 2009.
<p>Percent of participants with depressed BChE activity relative to the normal ranges in 2005 and 2009.</p