Studies on the Spectra of Protoberberine Alkaloids. II. Absorption Spectrum of Jatrorrhizine

Measurements have been made on the visible and UV absorption spectra of jatrorrhizine chloride in pure aqueous, methanol, ethanol a nd propa nol solutions and in the p resence of various concentrations of e ither hydrochloric acid or potass ium h ydroxid e. In all the solutions, potassium hydroxide conside rably modifies the absorption curves. The modifications b ecome manifest in the disappearance of the absorption maximum and in the appearance of new bathochromic shifted maxima. In these changes isobestic points were noticed in the absorption curves. At very high potassium hydroxide concentrations in ethanol and propanol solutions, the absorption maximum disappears from the vis ible region of the spectrum. It has been suggested that the addition of potassium hydroxide causes the formation of the quinonoidic form of jatrorrhizine. The carbinolic form probably appears only in ethanol and propanol solutions

Syntheses and Spectrophotometric Studies of Some New Aralkyl Pyridinium Oximes

Syntheses and some physical properties of seven aralkyl pyridinium oximes, potential antidotes against organophosphorus poisons and potential reagents for pentacyano compounds of iron, are described and discussed. Their UV absorption spectra in water and in water-dioxane solutions at different pH values have been measured. The spectral changes with changing pH in aqueous solutions are attributed to the dissociati.on of individual functional groups of the compounds, and in water-dioxane mixtures they are attributed to the polarities of the solvents. One equilibrium is established in most of the compounds, however, in PhPA-4 and PhOPA-4 two equilibria exist. The dissociation constants of all compounds have been determined spectrophotometrically. The pK\u27s of the compounds are discussed in terms of the structure of the compounds. A spectrophotometric method for the determination of the examined compounds is proposed

Tödliche Vergiftungen in Zagreb und Umgebung

Izvršena je analiza smrtnih slučajeva otrovanja na području grada Zagreba i njegove okolice za period od 1934. do 1967. godine, tj. od osnutka Instituta do 1967. godine. Rezultati analize prikazani su tabelarno po godinama. načinu otrovanja (nesretni slučajevi, samoubojstva i ubistva), grupama otrova. životnoj dobi smrtno otrovanih, spolu i profesiji. Podaci za ovu analizu dobiveni su uvidom u arhiv Instituta za sudsku medicinu i kriminalistiku Medicinskog fakulteta u ZagrebuEs wurde eine Analyse der Fälle tödlicher Vergiftungen auf dem Gebiet der Stadt Zagreb und ihrer Umgebung für den Zeitraum von 1934 bis 1967, d. h. vom Beginn der Arbeit des Instituts bis 1967, durchgeführt. Die Resultate der Analyse werden in Tabellen aufgezeigt. und zwar nach den Jahren des Geschehens, nach der Vergiftungsart (Unglücksfälle, Selbstmorde, Morde) nach Giftgruppen und ichlierslich entsprechend dem Alter, Geschlecht und Profession der tödlich Vergifteten. Die Daten für diese Analyse wurden aus dem Archiv des Instituts entnommen

The UV and VIS Absorption Spectra of Jatrorubine

The absorption spectra of water, methanolic, ethanolic and propanolic solutions of jatrorubine in the VIS and UV spectral range were recorded. The acidity and the alkalinity of the solutions were changed in the wide range from pH = 2 to pH = 13 by the addition of KOH and HCl in the solutions. From the influence of pH on the shapes of the absorption curves, it was concluded that jatrorubine exists as quaternary aminic cation in the acidic medium and as the resonance dipole molecula in the basic media, but no evidence for the existence of carbinolic form was found. The results were compared with the literature data

Studies on the spectra of protoberberine alkaloids. I. Absorption spectrum of Berberine

Measurements have been made of the visible and UV absorption spectra of berberine chloride in pure aqueous, methanol, ethanol and propanol solutions and in the presence of various concentrations of either hydrochloric acid or potassium hydroxide. In all solutions, potassium hydroxide considerably influences both the form of the absorption curves and the values of the extinction coefficients. Bathochromic shifts (red s hift s) of the ab sorption maxima were observed in the ultra-violet spectrum and the disappearence of the absorption maxima in the visible. It has been suggested that the addition of potassium hydroxide causes the formation of the carbinolic form of berberine in all but the aqueous solutions. The open carbinol form is probably formed in the presence of l arge concentrations of KOH. It was found that the shapes of the absorption curves of berberine in the presence of KOH differ widely in different solvents