Incommensurate and multiple-q\boldsymbol{q} magnetic misfit order in the frustrated quantum spin ladder material antlerite, Cu3_3SO4_4(OH)4_4

In frustrated magnetic systems, the competition amongst interactions can introduce extremely high degeneracy and prevent the system from readily selecting a unique ground state. In such cases, the magnetic order is often exquisitely sensitive to the balance among the interactions, allowing tuning among novel magnetically ordered phases. In antlerite, Cu$_3$SO$_4$(OH)$_4$, Cu$^{2+}$ ($S=1/2$) quantum spins populate three-leg zigzag ladders in a highly frustrated quasi-one-dimensional structural motif. We demonstrate that at zero applied field, in addition to its recently reported low-temperature phase of coupled ferromagnetic and antiferromagnetic spin chains, this mineral hosts an incommensurate helical+cycloidal state, an idle-spin state, and a multiple-$q$ phase which is the magnetic analog of misfit crystal structures. The antiferromagnetic order on the central leg is reentrant. The high tunability of the magnetism in antlerite makes it a particularly promising platform for pursuing exotic magnetic order.Comment: 18.3 pages, 16 Figures, follow-up paper to arXiv:2203.1534

TILGen: A Program to Investigate Immune Targets in Breast Cancer Patients - First Results on the Influence of Tumor-Infiltrating Lymphocytes

Background: Despite advancements in the treatment of primary and metastatic breast cancer, many patients lack a durable response to these treatments. Patients with triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2(HER2)-positive breast cancer who do not have a pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) have a very poor prognosis. Tumor-infiltrating lymphocytes (TILs) have been identified as a predictive marker for pCR after NACT in TNBC and HER2-positive breast cancer. These patient populations could also be suitable for novel treatment strategies including neoepitope-based therapies. This work analyses the effect of TILs on the pCR in neoadjuvantly treated patients in the TILGen study and presents the procedures aimed at establishing neoepitope-based therapies in this study. Methods: Neoadjuvantly treated HER2-positive and TNBC patients were eligible for the presented analysis concerning the association between TILs and pCR. A total of 146 patients could be identified within the TILGen study. TILs were evaluated as percentage of stromal tumor tissue in core biopsies at primary diagnosis. The phenotype ‘lymphocyte-predominant breast cancer' (LPBC) was associated with pCR by logistic regression adjusted for estrogen receptor status, progesterone receptor status, HER2 status, age at diagnosis, and grading. Results: LPBC was seen in 24 (16.4%) patients. In this patient group, 66.7% achieved a pCR, while the pCR rate was 32.8% in patients with a low TIL count. The adjusted odds ratio was 6.60 (95% confidence interval 2.02-21.56; p < 0.01). Conclusion: TILs are a strong predictor of pCR in TNBC and HER2-positive breast cancer patients. Implications for the use of this information including the effect on prognosis might help to identify patients most likely to benefit from a neoepitope-based therapy approach

WeChange - Eine demografiesensible Supportplattform zur Wissensvernetzung im Unternehmen

Eine wichtige Herausforderung zur Erhaltung der Innovationsfähigkeit von Unternehmen ist die Gestaltung der organisationalen Informationstechnologien (IT). Der demografische Wandel geht einher mit Veränderungen im Nutzungsverhalten von IT. Allgemein ist die Bedeutung von IT im privaten Umfeld in den letzten Jahren stetig gewachsen. Die Vorlieben bezüglich der Technologienutzung unterscheiden sich dabei zum Teil erheblich und lassen sich nicht immer mit organisationalen Anforderungen in Einklang bringen. Die steigende Heterogenität der Arbeitnehmer, unterstützt durch demografische Entwicklungen, führt inzwischen dazu, dass immer mehr verschiedene Hard- und Software in Unternehmen eingesetzt werden. Für die IT-Abteilung wird es so zunehmend schwieriger, einen zentralen Support bereitzustellen. Zur gleichen Zeit sind Nutzer von Technologie inzwischen deutlich versierter in deren Umgang, so dass sie viele Probleme entweder selbst oder untereinander lösen können. Hier setzt die Idee des dezentralen Supports an, in der sich Nutzer direkt miteinander vernetzen, um gegenseitig Supportanfragen zu lösen. Im Forschungsprojekt WeChange wurde eine demografiesensible dezentrale Supportplattform entwickelt, die auf die Bedürfnisse der Unternehmen und Nutzer zugeschnitten ist. Kern der Plattform ist die dezentrale Interaktion zwischen Nutzern, die anstatt prozess-orientierten Strukturen zu folgen, die Vorteile sozialer Vernetzung nutzt

Chemical Aspects of the Candidate Antiferromagnetic Topological Insulator MnBi2Te4MnBi_{2}Te_{4}

High-quality single crystals of MnBi2Te4 are grown for the first time by slow cooling within a narrow range between the melting points of Bi$_2$Te$_3$ (586 °C) and MnBi$_2$Te$_4$ (600 °C). Single-crystal X-ray diffraction and electron microscopy reveal ubiquitous antisite defects in both cation sites and, possibly, Mn vacancies (Mn$_{0.85(3)}$Bi$_{2.10(3)}$Te$_4$). Thermochemical studies complemented with high-temperature X-ray diffraction establish a limited high-temperature range of phase stability and metastability at room temperature. Nevertheless, the synthesis of MnBi$_2$Te$_4$ can be scaled-up as powders can be obtained at subsolidus temperatures and quenched at room temperature. Bulk samples exhibit long-range antiferromagnetic ordering below 24 K. The Mn(II) out-of-plane magnetic state is confirmed by the magnetization, X-ray photoemission, X-ray absorption, and linear dichroism measurements. The compound shows a metallic type of resistivity in the range 4.5–300 K and is an n-type conductor that reaches a thermoelectric figure of merit up to ZT = 0.17. Angle-resolved photoemission experiments show a surface state forming a gapped Dirac cone, thus strengthening MnBi$_2$Te$_4$ as a promising candidate for the intrinsic magnetic topological insulator, in accordance with theoretical predictions. The developed synthetic protocols enable further experimental studies of a crossover between magnetic ordering and nontrivial topology in bulk MnBi$_2$Te$_4$