157 research outputs found
New Precision Electroweak Tests of SU(5) x U(1) Supergravity
We explore the one-loop electroweak radiative corrections in supergravity via explicit calculation of vacuum-polarization and
vertex-correction contributions to the and
parameters. Experimentally, these parameters are obtained from a global fit to
the set of observables , and . We
include -dependent effects, which induce a large systematic negative shift
on for light chargino masses (m_{\chi^\pm_1}\lsim70\GeV). The
(non-oblique) supersymmetric vertex corrections to \Zbb, which define the
parameter, show a significant positive shift for light chargino
masses, which for can be nearly compensated by a negative
shift from the charged Higgs contribution. We conclude that at the 90\%CL, for
m_t\lsim160\GeV the present experimental values of and
do not constrain in any way supergravity in
both no-scale and dilaton scenarios. On the other hand, for m_t\gsim160\GeV
the constraints on the parameter space become increasingly stricter. We
demonstrate this trend with a study of the m_t=170\GeV case, where only a
small region of parameter space, with \tan\beta\gsim4, remains allowed and
corresponds to light chargino masses (m_{\chi^\pm_1}\lsim70\GeV). Thus
supergravity combined with high-precision LEP data would
suggest the presence of light charginos if the top quark is not detected at the
Tevatron.Comment: LaTeX, 11 Pages+4 Figures(not included), the figures available upon
request as an uuencoded file(0.4MB) or 4 PS files from [email protected],
CERN-TH.7078/93, CTP-TAMU-68/93, ACT-24/9
Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation.
The crystal structure of Dhaf4260 from Desulfitobacterium hafniense DCB-2 was determined by single-wavelength anomalous diffraction (SAD) to a resolution of 2.01â
Ă
using the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics (JCSG) as part of the NIGMS Protein Structure Initiative (PSI). This protein structure is the first representative of the PF04016 (DUF364) Pfam family and reveals a novel combination of two well known domains (an enolase N-terminal-like fold followed by a Rossmann-like domain). Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The genome context of Dhaf4260 and homologs additionally supports a role in heavy-metal chelation
Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15.
The crystal structure of a putative NTPase, YP_001813558.1 from Exiguobacterium sibiricum 255-15 (PF09934, DUF2166) was determined to 1.78â
Ă
resolution. YP_001813558.1 and its homologs (dimeric dUTPases, MazG proteins and HisE-encoded phosphoribosyl ATP pyrophosphohydrolases) form a superfamily of all-α-helical NTP pyrophosphatases. In dimeric dUTPase-like proteins, a central four-helix bundle forms the active site. However, in YP_001813558.1, an unexpected intertwined swapping of two of the helices that compose the conserved helix bundle results in a `linked dimer' that has not previously been observed for this family. Interestingly, despite this novel mode of dimerization, the metal-binding site for divalent cations, such as magnesium, that are essential for NTPase activity is still conserved. Furthermore, the active-site residues that are involved in sugar binding of the NTPs are also conserved when compared with other α-helical NTPases, but those that recognize the nucleotide bases are not conserved, suggesting a different substrate specificity
Structure of the Îł-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-Îł-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases.
Dipeptidyl-peptidase VI from Bacillus sphaericus and YkfC from Bacillus subtilis have both previously been characterized as highly specific Îł-D-glutamyl-L-diamino acid endopeptidases. The crystal structure of a YkfC ortholog from Bacillus cereus (BcYkfC) at 1.8â
Ă
resolution revealed that it contains two N-terminal bacterial SH3 (SH3b) domains in addition to the C-terminal catalytic NlpC/P60 domain that is ubiquitous in the very large family of cell-wall-related cysteine peptidases. A bound reaction product (L-Ala-Îł-D-Glu) enabled the identification of conserved sequence and structural signatures for recognition of L-Ala and Îł-D-Glu and, therefore, provides a clear framework for understanding the substrate specificity observed in dipeptidyl-peptidase VI, YkfC and other NlpC/P60 domains in general. The first SH3b domain plays an important role in defining substrate specificity by contributing to the formation of the active site, such that only murein peptides with a free N-terminal alanine are allowed. A conserved tyrosine in the SH3b domain of the YkfC subfamily is correlated with the presence of a conserved acidic residue in the NlpC/P60 domain and both residues interact with the free amine group of the alanine. This structural feature allows the definition of a subfamily of NlpC/P60 enzymes with the same N-terminal substrate requirements, including a previously characterized cyanobacterial L-alanine-Îł-D-glutamate endopeptidase that contains the two key components (an NlpC/P60 domain attached to an SH3b domain) for assembly of a YkfC-like active site
Probing Supergravity Models with Indirect Experimental Signatures
We explore the one-loop electroweak radiative corrections in the context of
the traditional minimal and the string-inspired
supergravity models by calculating explicitly vacuum-polarization and
vertex-correction contributions to the and
parameters. We also include in this analysis the constraint from whose inclusive branching ratio has been
actually measured very recently by CLEO. We find that by combining these three
most important indirect experimental signatures and using the most recent
experimental values for them, is excluded for
in both the minimal supergravity and the no-scale supergravity. We also find that is
excluded for any sign of in the minimal () supergravity
model.Comment: RevTeX 3.0, 16 Pages+4 figures(not included but available as a
uuencoded file from [email protected]), SNUTP-94-9
The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.
Proteins that contain the DUF2874 domain constitute a new Pfam family PF11396. Members of this family have predominantly been identified in microbes found in the human gut and oral cavity. The crystal structure of one member of this family, BVU2987 from Bacteroides vulgatus, has been determined, revealing a ÎČ-lactamase inhibitor protein-like structure with a tandem repeat of domains. Sequence analysis and structural comparisons reveal that BVU2987 and other DUF2874 proteins are related to ÎČ-lactamase inhibitor protein, PepSY and SmpA_OmlA proteins and hence are likely to function as inhibitory proteins
Precision Electroweak Tests of the Minimal and Flipped SU(5) Supergravity Models
We explore the one-loop electroweak radiative corrections in the minimal
and the no-scale flipped supergravity models via explicit
calculation of vacuum polarization contributions to the
parameters. Experimentally, are obtained from a global fit
to the LEP observables, and measurements. We include -dependent
effects which have been neglected in most previous ``model-independent"
analyses of this type. These effects induce a large systematic negative shift
on for light chargino masses (m_{\chi^\pm_1}\lsim70\GeV).
In agreement with previous general arguments, we find that for increasingly
large sparticle masses, the heavy sector of both models rapidly decouples, \ie,
the values for quickly asymptote to the Standard Model
values with a {\it light} Higgs (m_{H_{SM}}\sim100\GeV). Specifically, at
present the CL upper limit on the top-quark mass is m_t\lsim175\GeV in
the no-scale flipped supergravity model. These bounds can be
strengthened for increasing chargino masses in the 50-100\GeV interval. In
particular, for m_t\gsim160\GeV, the Tevatron may be able to probe through
gluino() and squark() production up to m_{\tilde g}\approx
m_{\tilde q}\approx250\GeV, exploring at least half of the parameter space in
this model.Comment: 15 pages,(6 ps figures available upon request), TeX(harvmac),
CTP-TAMU-19/93, ACT-07/9
Experimental aspects of SU(5)xU(1) supergravity
We study various aspects of supergravity as they relate to
the experimental verification or falsification of this model. We consider two
string-inspired, universal, one-parameter, no-scale soft-supersymmetry-breaking
scenarios, driven by the -terms of the moduli and dilaton fields. The model
is described in terms of the supersymmetry mass scale (\ie, the chargino mass
), , and the top-quark mass. We first determine the
combined effect on the parameter space of all presently available direct and
indirect experimental constraints, including the LEP lower bounds on sparticle
and Higgs-boson masses, the rate, the anomalous magnetic moment
of the muon, the high-precision electroweak parameters
(which imply m_t\lsim180\GeV), and the muon fluxes in underground detectors
(neutrino telescopes). For the still-allowed points in
parameter space, we re-evaluate the experimental
situation at the Tevatron, LEPII, and HERA. In the 1994 run, the Tevatron could
probe chargino masses as high as 100 GeV. At LEPII the parameter space could be
explored with probes of different resolutions: Higgs boson searches, selectron
searches, and chargino searches. Moreover, for m_t\lsim150\GeV, these
Higgs-boson searches could explore all of the allowed parameter space with
\sqrt{s}\lsim210\GeV.Comment: latex, 36 pages, 25 figures (not included). Figures are available via
anonymous ftp from hplaa02.cern.ch (/pub/lopez) as either 33 ps files
(Easpects*.ps, 8.1MB) or one uuencoded file (AllFigures.uu, 3.7MB
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