Effect of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on peritoneal dialysis and hemodialysis

Background: Several medications have been tested with the aim of decreasing oxidative stress and erythrocyte osmotic fragility in patients on dialysis. The aim of the present study was to assess the influence of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on hemodialysis (HD) and peritoneal dialysis (PD)

Alterations in lipid peroxidation and antioxidant status in different types of intracranial tumors within their relative peritumoral tissues

Objectives: Elevated levels of lipid peroxidation and changes in the concentration of enzymatic and nonenzymatic antioxidant systems have been reported in various cancers, but there are very few reports available of lipid peroxidation due to oxidative stress in patients with intracranial neoplasms. The purpose of this study was to assess alterations in lipid peroxidation and antioxidant status in different types of tumors and to compare the results with their relative peritumoral tissues and compare the oxidative status in different grades of tumors

Inhibition of inducible nitric oxide synthase in murine visceral larva migrans: Effects on lung and liver damage

The roles of nitric oxide production and oxidative process were studied in mice infected with Toxocara canis and treated with aminoguanidine which is a specific inhibitor of inducible nitric oxide synthase (iNOS). Relations of nitric oxide synthase inhibition and tissue pathology were assessed by biochemical, histological and immunohistochemical methods. In experiments, Balb/c albino mice were inoculated with T. canis eggs either with or without aminoguanidine treatment or alone, at 24(th), 48(th) hours and on 7(th) days. LPx and SOD values in liver tissue and plasma were measured. Liver and lung tissues were evaluated for the pathological lesions. The expression of eNOS and iNOS in both tissues were studied with immunohistochemistry in the same intervals. We observed significant differences between T. canis infected and aminoguanidine treated animals. Larval toxocarosis led to oxidative stress elevation in plasma. Microscopic examination of the liver histological sections revealed pathological lesions in the hepatic parenchyma in infected mice. In the mice received T. canis eggs plus aminoguanidine, the sinusoidal areas were enlarged. Histological lesions were more severe at 48 hours after infection. Numbers of eNOS and iNOS expressing epithelial cells were increased in the T. canis infected mice. The activities of eNOS and iNOS were also observed in the body of the larvae which have migrated to lung and liver. As a result, we have demonstrated that in vivo production of eNO and iNO during T. canis infection cause direct host damages and it is strongly related to the oxidative stress. We propose that larval NO can also be effective in larval migration, but it needs further investigation on distribution of NO in larvae

Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients

Background: Previous studies have suggested the importance of redox regulation in carcinogenesis. The aim of this study was to evaluate the prognostic role of altered redox homeostasis and oxidative DNA damage in patients with breast carcinoma before and during two cycles of chemotherapy

Effects of iloprost on lipid peroxidation parameters in cerebral hypoperfusion model induced by right common carotid artery occlusion

Our aim was to study effects of iloprost on lipid peroxidation parameters in cerebral hypoperfusion model induced by right common carotid artery occlusion. The rats were divided into 4 weight-matched groups. Sham-operated group (S) (n=10); Hypoperfused (H) (n=10); Early iloprost administered after hypoperfusion (HE) (n= 10); Late iloprost administered after hypoperfusion (HQ (n=10). Plasma MDA levels of H, HE and HL groups were significantly higher than S group (respectively p<0.001. p<0.05. p<0.001). Values of intraerythrocytic Cu-Zn SOD activity of H. HE and HL groups were significantly higher than those of S group (p<0.001). The right hemisphere tissue MDA levels of S group were highest (P<0.05). HE group right hemisphere Cu-Zn SOD activity was higher than other groups, on the other hand HL group right hemisphere Cu-Zn SOD activity significantly lower than other groups (p<0.001). Our findings revealed that the early iloprost treatment might be protected the brain tissue from oxidative damage