Evolving approaches and resources for clinical practice in the management of HIV infection in the HAART era

Physicians treating HIV infection concentrate not only on the viral management but they also have to take into account the potential age and lifestyle-related conditions likely to influence long-term morbidity, correlated with patients' survival. Hypertension, diabetes, cardiovascular, bone, kidney and liver disease, better than opportunistic infection, depict the changing spectrum of HIV disease in the HAART era. These conditions, the so called non infectious co-morbidities, are age-related diseases affecting the general population. However, their prevalence in HIV-infected individuals is higher, with earlier onset, probably as a result of the complex inter-relationship between HIV infection, co-infection and antiretroviral therapy. Regular screening for non infectious co-morbidities helps identify those asymptomatic HIV-infected individuals who are most at risk of developing comorbidities; this means that appropriate intervention, either by lifestyle changes to reduce modifiable risk factors or by the use of pharmacological management, can be initiated. © GERMS 2011

The transition from co-morbidities to geriatric syndromes in HIV.

Several recent cohort studies have suggested that life expectancy of HIV-infected individuals is currently comparable to that of the general population, particularly when antiretroviral therapy (ART) was initiated at earlier disease stages.1 Simultaneously, HIV seroconversion among older age persons is increasingly recognized, in part as the result of lower perceptions of sexual risk in older people.2 The overall effect is one of advancing age among HIV-infected persons, with a recognition that persons who age with HIV infection have an increased burden of age-related comorbid illnesses compared to persons of a similar age who were more recently HIV-infected

Geriatric-HIV medicine: A science in its infancy

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Urolithiasis associated with atazanavir may mask a metabolic 'channelling' bias.

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Cardiovascular Risk Prediction in Patients With Human Immunodeficiency Virus

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Facial lipohypertrophy in HIV-infected subjects who underwent autologous fat tissue transplantation.

Of 41 HIV-infected patients with facial lipoatrophy who underwent autologous fat transplantation, disfiguring facial lipohypertrophy at the graft site occurred at the same time as recurrent fat accumulation at the tissue harvest site in 4 patients who had had fat transferred from the dorsocervical fat pad or from subcutaneous abdominal tissue

Cardiovascular disease in human immunodeficiency virus infected patients: A true or perceived risk?

After the successful introduction of highly active antiretroviral agents the survival of patients infected with the human immunodeficiency virus (HIV) in developed countries has increased substantially. This has allowed the surfacing of several chronic diseases among which cardiovascular disease (CVD) is prominent. The pathogenesis of CVD in HIV is complex and involves a combination of traditional and HIV related factors. An accurate assessment of risk of CVD in these patients is still elusive and as a consequence the most appropriate preventive and therapeutic interventions remain controversial

Geriatric syndromes: How to treat

The survival of HIV-infected persons has been increasing over the last years, thanks to the implementation of more effective pharmacological and non-pharmacological interventions. Nevertheless, HIV-infected persons are often \u201cbiologically\u201d older than their \u201cchronological\u201d age due to multiple clinical, social, and behavioral conditions of risk. The detection in this population of specific biological features and syndromic conditions typical of advanced age has made the HIV infection an interesting research model of accelerated and accentuated aging. Given such commonalities, it is possible that \u201cbiologically aged\u201d HIV-positive persons might benefit from models of adapted and integrated care developed over the years by geriatricians for the management of their frail and complex patients. In this article, possible strategies to face the increasingly prevalent geriatric syndromes in HIV-infected persons are discussed. In particular, it is explained the importance of shifting from the traditional disease-oriented approach into models of care facilitating a multidisciplinary management of frailty

Management of human immunodeficiency virus in older people

The proportion of older (aged ≥50 years) people living with human immunodeficiency virus (PLHIV) within the HIV-positive population is increasing. Many comorbidities associated with ageing are observed more frequently and/or occur at an earlier age among PLHIV, compared with people who are uninfected