In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

The research was supported by the Government of the RF (grant 14.Z50.31.0004 to support scientific research projects implemented under the supervision of leading scientists)

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

This work was supported by the Government of the Russian Federation (grant 14.Z50.31.0004 to support scientific research projects implemented under the supervision of leading scientists at Russian Institutions and Russian Institutions of Higher Education)

In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast

crosscheck: This document is CrossCheck deposited related_data: Supplementary Information identifier: Nikita A. Navolokin (ResearcherID) copyright_licence: The PCCP Owner Societies have an exclusive publication licence for this journal history: Received 5 June 2016; Accepted 23 October 2016; Accepted Manuscript published 1 November 2016; Advance Article published 16 November 2016; Version of Record published 30 November 201

Cell Mediated Photothermal Therapy of Brain Tumors

Gold based nanoparticles with strong near infra-red (NIR) absorption are ideally suited for photothermal therapy (PTT) of brain tumors. The goal of PTT is to induce rapid heating in tumor tissues while minimizing thermal diffusion to normal brain. PTT efficacy is sensitively dependent on both nanoparticle concentration and distribution in tumor tissues. Nanoparticle delivery via passive approaches such as the enhanced permeability and retention (EPR) effect is unlikely to achieve sufficient nanoparticle concentrations throughout tumor volumes required for effective PTT. A simple approach for improving tumor biodsitribution of nanoparticles is the use of cellular delivery vehicles. Specifically, this review focuses on the use of monocytes/macrophages (Mo/Ma) as gold nanoparticle delivery vectors for PTT of brain tumors. Although the efficacy of this delivery approach has been demonstrated in both in vitro and animal PTT studies, its clinical potential for the treatment of brain tumors remains uncertain