Henry James Goes to the Movies

Why has a nineteenth-century author with an elitist reputation proved so popular with directors as varied as William Wyler, François Truffaut, and James Ivory? A partial answer lies in the way many of Henry James’s recurring themes still haunt us: the workings of power, the position of women in society, the complexities of sexuality and desire. Susan Griffin has assembled fifteen of the world’s foremost authorities on Henry James to examine both the impact of James on film and the impact of film on James. Anthony Mazella traces the various adaptations of The Turn of the Screw, from novel to play to opera to film. Peggy McCormack examines the ways the personal lives of Peter Bogdanovich and then-girlfriend Cybill Shepherd influenced critical reaction to Daisy Miller (1974). Leland Person points out the consequences of casting Christopher Reeve—then better known as Superman—in The Bostonians (1984) during the conservative political context of the first Reagan presidency. Nancy Bentley defends Jane Campion’s anachronistic reading of Portrait of a Lady (1996) as being more “authentic” than the more common period costume dramas. Dale Bauer observes James’s influence on such films as Next Stop, Wonderland (1998) and Notting Hill (1999). Marc Bousquet explores the ways Wings of the Dove (1997) addresses the economic and cultural situations of Gen-X viewers. Other fascinating essays as well as a complete filmography and bibliography of work on James and film round out the collection. Susan M. Griffin, professor of English at the University of Louisville, is the editor of the Henry James Review. This collection of sophisticated essays contributes to a growing field that could be labeled ‘James film studies.’ —Choice The essays enrich a new field of James studies, as well as provide a fascinating account of more than fifty years of film history. —English Literature in Transition In this anthology of essays, 16 academics dissect novelist Henry James’s seemingly inexhaustible allure to filmmakers ranging from William Wyler to Jane Campion and examine the degrees to which these celluloid versions succeed in translating James’s highly uncinematic, psychological prose to the screen. —Entertainment Weekly The essay entitled ‘Based on the Novel by Henry James: The Golden Bowl 2000’ is one of the best I’ve ever read about the film adaptation of a difficult novel. —Film Quarterly A well-informed, well-written book which extends the way we think about Henry James and his work. . . . Includes the best established and newer voices in James studies. —Greg W. Zacharias A comprehensive, impressive collection of essays on film adaptations of Henry James. —Hollins Critic Indispensable for anyone interested in James adaptations. —Studies in the Novelhttps://uknowledge.uky.edu/upk_english_language_and_literature_north_america/1059/thumbnail.jp

Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co-ordination after spinal cord injury

Autologous cell transplantation is a promising strategy for repair of the injured spinal cord. Here we have studied the repair potential of mesenchymal stromal cells isolated from the human olfactory mucosa after transplantation into a rodent model of incomplete spinal cord injury. Investigation of peripheral type remyelination at the injury site using immunocytochemistry for P0, showed a more extensive distribution in transplanted compared with control animals. In addition to the typical distribution in the dorsal columns (common to all animals), in transplanted animals only, P0 immunolabelling was consistently detected in white matter lateral and ventral to the injury site. Transplanted animals also showed reduced cavitation. Several functional outcome measures including end-point electrophysiological testing of dorsal column conduction and weekly behavioural testing of BBB, weight bearing and pain, showed no difference between transplanted and control animals. However, gait analysis revealed an earlier recovery of co-ordination between forelimb and hindlimb stepping in transplanted animals. This improvement in gait may be associated with the enhanced myelination in ventral and lateral white matter, where fibre tracts important for locomotion reside. Autologous transplantation of mesenchymal stromal cells from the olfactory mucosa may therefore be therapeutically beneficial in the treatment of spinal cord injury

Path, place, and cover : observations in three Italian towns

Thesis. 1979. M.Arch--Massachusetts Institute of Technology. Dept. of Architecture.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.Bibliography: p. 104-107.by Karen Barned, Mary Griffin.M.Arc

Distributional impact of the Malawian Essential Health Package

In low- and middle-income countries (LMICs), making the best use of scarce resources is essential to achieving universal health coverage. The design of health benefits packages creates the opportunity to select interventions on the basis of explicit objectives. Distributional cost-effectiveness analysis (DCEA) provides a framework to evaluate interventions based on two objectives: increasing population health, and reducing health inequality. We conduct aggregate DCEA of potential health benefits package interventions to demonstrate the feasibility of this approach in LMICs, using the case of the Malawian health benefits package. We use publicly available survey and census data common to LMICs, and describe what challenges we encountered and how we addressed them. We estimate that diseases targeted by the health benefits package are most prevalent in the poorest population quintile and least prevalent in the richest quintile. The survey data we use indicates socioeconomic patterns in intervention uptake that diminish the population health gain and inequality reduction from the package. We find that a similar set of interventions would be prioritised when impact on health inequality is incorporated alongside impact on overall population health. However, conclusions about the impact of individual interventions on health inequalities are sensitive to assumptions regarding the health opportunity cost, the utilisation of interventions, the distribution of diseases across population groups, and the level of aversion to inequality. Our results suggest that efforts to improve access to the essential health package could be targeted to specific interventions to improve the health of the poorest fastest, but that identifying these interventions is uncertain. This exploratory work has shown the potential for applying the DCEA framework to inform health benefits package design within the LMIC setting, and to provide insight into the equity impact of a health benefits package

Exact P-values for Network Interference

We study the calculation of exact p-values for a large class o f non- sharp null hypotheses about treatment effects in a setting wi th data from experiments involving members of a single connected ne twork. The class includes null hypotheses that limit the effect of on e unit’s treatment status on another according to the distance betwe en units; for example, the hypothesis might specify that the treatmen t status of immediate neighbors has no effect, or that units more than two edges away have no effect. We also consider hypotheses concerning t he valid- ity of sparsification of a network (for example based on the st rength of ties) and hypotheses restricting heterogeneity in peer effe cts (so that, for example, only the number or fraction treated among neigh boring units matters). Our general approach is to define an artificia l experi- ment, such that the null hypothesis that was not sharp for the original experiment is sharp for the artificial experiment, and such t hat the randomization analysis for the artificial experiment is val idated by the design of the original experiment

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease, providing compelling evidence that high blood cholesterol concentrations cause atherosclerosis. In this study, we used 1H nuclear magnetic resonance spectroscopy to examine the metabolic profiles of plasma and urine from the LDLR knockout mice. Consistent with previous studies, these mice developed hypercholesterolemia and atherosclerosis when fed a high-fat/cholesterol/cholate-containing diet. In addition, multivariate statistical analysis of the metabolomic data highlighted significant differences in tricarboxylic acid cycle and fatty acid metabolism, as a result of high-fat/cholesterol diet feeding. Our metabolomic study also demonstrates that the effect of high-fat/cholesterol/cholate diet, LDLR gene deficiency, and the diet-genotype interaction caused a significant perturbation in choline metabolism, notably the choline oxidation pathway. Specifically, the loss in the LDLR caused a marked reduction in the urinary excretion of betaine and dimethylglycine, especially when the mice are fed a high-fat/cholesterol/cholate diet. Furthermore, as we demonstrate that these metabolic changes are comparable with those detected in ApoE knockout mice fed the same high-fat/cholesterol/cholate diet they may be useful for monitoring the onset of atherosclerosis across animal models

Methods to place a value on additional evidence are illustrated using a case study of corticosteroids after traumatic brain injury

Objectives\ud To establish whether evidence about the effectiveness of a health care intervention is sufficient to justify the use of the intervention in practice and show how value of information (VOI) analysis can be used to place a value on the need for additional evidence and inform research prioritization decisions.\ud \ud Study Design and Setting\ud Meta-analysis provides an estimate of the effect of an intervention with uncertainty. VOI analysis determines the adverse health consequences of not resolving this uncertainty. A case study examining the evidence before the high profile trial of Corticosteroid Randomisation After Significant Head injury (CRASH) shows the consequences on patient outcomes if this trial had not been successfully funded.\ud \ud Results\ud The consequences of uncertainty before CRASH were high at 40 deaths and 1,067 years of full health per annum. VOI analysis indicates that CRASH was worthwhile and the UK National Health Service would have had to spend an additional £205 million elsewhere to generate health benefits similar to CRASH.\ud \ud Conclusions\ud VOI analysis can be integrated with the results of meta-analysis to help inform whether a particular research proposal is potentially worthwhile and whether it should be prioritized over other research topics that could be commissioned with the same resource

Impact of Making Dental Care Affordable on Quality of Life in Adults Aged 45 Years and Older

Objective: The objective of this study was to examine the associations between self-reported ability to afford dental care and quality of life in adults aged 45 years and older. Method: We used publicly available cross-sectional data from the 2008 National Health Interview Survey and its oral health supplement for 11,760 adults aged 45+ years. The increased probabilities of reporting dental problems attributable to an inability to afford dental care were estimated from multivariate models and combined with respective dental problem disability weights from the Global Burden of Disease to measure loss in quality of life. Results: Prevalence of reported inability to afford dental care, severe tooth loss, severe periodontitis, and untreated caries were 11.9%, 8.5%, 14.3%, and 37.9%, respectively. Inability to afford dental care was associated with an increase of 0.017 disability-adjusted life-years (DALYs) per person per year under base case and 0.020 DALYs under generous assumptions. Conclusion: Making dental care affordable could improve adult’s (age 45 and above) quality of life at a reasonable cost