Long-term aircraft noise exposure and risk of hypertension in postmenopausal women

Background: Studies of the association between aircraft noise and hypertension are complicated by inadequate control for potential confounders and a lack of longitudinal assessments, and existing evidence is inconclusive. Objectives: We evaluated the association between long-term aircraft noise exposure and risk of hypertension among post-menopausal women in the Women's Health Initiative Clinical Trials, an ongoing prospective U.S. cohort. Methods: Day-night average (DNL) and night equivalent sound levels (Lnight) were modeled for 90 U.S. airports from 1995 to 2010 in 5-year intervals using the Aviation Environmental Design Tool and linked to participant geocoded addresses from 1993 to 2010. Participants with modeled exposures ≥45 A-weighted decibels (dB [A]) were considered exposed, and those outside of 45 dB(A) who also did not live in close proximity to unmodeled airports were considered unexposed. Hypertension was defined as systolic/diastolic blood pressure ≥140/90 mmHg or inventoried/self-reported antihypertensive medication use. Using time-varying Cox proportional hazards models, we estimated hazard ratios (HRs) for incident hypertension when exposed to DNL or Lnight ≥45 versus <45 dB(A), controlling for sociodemographic, behavioral, and environmental/contextual factors. Results/discussion: There were 18,783 participants with non-missing DNL exposure and 14,443 with non-missing Lnight exposure at risk of hypertension. In adjusted models, DNL and Lnight ≥45 db(A) were associated with HRs of 1.00 (95% confidence interval [CI]: 0.93, 1.08) and 1.06 (95%CI: 0.91, 1.24), respectively. There was no evidence supporting a positive exposure-response relationship, and findings were robust in sensitivity analyses. Indications of elevated risk were seen among certain subgroups, such as those living in areas with lower population density (HRinteraction: 0.84; 95%CI: 0.72, 0.98) or nitrogen dioxide concentrations (HRinteraction: 0.82; 95%CI: 0.71, 0.95), which may indicate lower ambient/road traffic noise. Our findings do not suggest a relationship between aircraft noise and incident hypertension among older women in the U.S., though associations in lower ambient noise settings merit further investigation

Observational diagnostics of gas in protoplanetary disks

Protoplanetary disks are composed primarily of gas (99% of the mass). Nevertheless, relatively few observational constraints exist for the gas in disks. In this review, I discuss several observational diagnostics in the UV, optical, near-IR, mid-IR, and (sub)-mm wavelengths that have been employed to study the gas in the disks of young stellar objects. I concentrate in diagnostics that probe the inner 20 AU of the disk, the region where planets are expected to form. I discuss the potential and limitations of each gas tracer and present prospects for future research.Comment: Review written for the proceedings of the conference "Origin and Evolution of Planets 2008", Ascona, Switzerland, June 29 - July 4, 2008. Date manuscript: October 2008. 17 Pages, 6 graphics, 134 reference

Optical photometry of GM Cep: evidence for UXor type of variability

Results from optical photometric observations of the pre-main sequence star GM Cep are reported in the paper. The star is located in the field of the young open cluster Trumpler 37 - a region of active star formation. GM Cep shows a large amplitude rapid variability interpreted as a possible outburst from EXor type in previous studies. Our data from BVRI CCD photometric observations of the star are collected from June 2008 to February 2011 in Rozhen observatory (Bulgaria) and Skinakas observatory (Crete, Greece). A sequence of sixteen comparison stars in the field of GM Cep was calibrated in the BVRI bands. Our photometric data for a 2.5 years period show a high amplitude variations (Delta V ~ 2.3m) and two deep minimums in brightness are observed. The analysis of collected multicolor photometric data shows the typical of UX Ori variables a color reversal during the minimums in brightness. On the other hand, high amplitude rapid variations in brightness typical for the Classical T Tauri stars also present on the light curve of GM Cep. Comparing our results with results published in the literature, we conclude that changes in brightness are caused by superposition of both: (1) magnetically channeled accretion from the circumstellar disk, and (2) occultation from circumstellar clouds of dust or from features of a circumstellar disk.Comment: 7 pages, 3 figures, accepted for publication in Ap&S

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

Developmental epileptic encephalopathies are devastating disorders characterized by intractable epileptic seizures and developmental delay. Here, we report an allelic series of germline recessive mutations in UGDH in 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia. UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Consistent with being loss-of-function alleles, we show using patients’ primary fibroblasts and biochemical assays, that these mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease. Our study defines UGDH as a key player for the production of extracellular matrix components that are essential for human brain development. Based on the incidence of variants observed, UGDH mutations are likely to be a frequent cause of recessive epileptic encephalopathy

Hepcidin and Hfe in iron overload in beta-thalassemia

Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages. We showed that mice with beta-thalassemia intermedia (th3/+) have increased anemia and iron overload. However, their hepcidin expression is relatively low compared to their iron burden. We also showed that the iron metabolism gene Hfe is down-regulated in concert with hepcidin in th3/+ mice. These observations suggest that low hepcidin levels are responsible for abnormal iron absorption in thalassemic mice and that down-regulation of Hfe might be involved in the pathway that controls hepcidin synthesis in beta-thalassemia. Therefore, these studies suggest that increasing hepcidin and/or Hfe expression could be a strategy to reduces iron overload in these animals. The goal of this paper is to review recent findings that correlate hepcidin, Hfe, and iron metabolism in beta-thalassemia and to discuss potential novel therapeutic approaches based on these recent discoveries

Variability of disk emission in pre-main sequence and related stars. v. occultation events from the innermost disk region of the herbig ae star hd 163296

HD 163296 is a Herbig Ae star that underwent a dramatic ~0.8 magnitude drop in brightness in the V photometric band in 2001 and a brightening in the near-IR in 2002. Because the star possesses Herbig-Haro objects traveling in outflowing bipolar jets, it was suggested that the drop in brightness was due to a clump of dust entrained in a disk wind, blocking the line of sight toward the star. In order to quantify this hypothesis, we investigated the brightness drop at visible wavelengths and the brightening at near-IR wavelengths of HD 163296 using the Monte Carlo Radiative Transfer Code, HOCHUNK3D. We created three models to understand the events. Model 1 describes the quiescent state of the system. Model 2 describes the change in structure that led to the drop in brightness in 2001. Model 3 describes the structure needed to produce the observed 2002 brightening of the near-IR wavelengths. Models 2 and 3 utilize a combination of a disk wind and central bipolar flow. By introducing a filled bipolar cavity in Models 2 and 3, we were able to successfully simulate a jet-like structure for the star with a disk wind and created the drop and subsequent increase in brightness of the system. On the other hand, when the bipolar cavity is not filled, Model 1 replicates the quiescent state of the system. © 2021 Institute of Physics Publishing. All rights reserved.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]