21 research outputs found
Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients
Aim: Focal adhesion kinase (FAK) is an enzyme of the tyrosine kinase
group linked to signaling pathways between cells and their extracellular
matrix. FAK expression in tumor cells in vitro may correlate with their
ability for invasion and metastasis.
Methods: FAK protein expression was examined immunohistochemically in 80
cases of colon adenocarcinoma, and correlated with clinicopathological
parameters; tumor proliferative capacity, reflected by Ki-67 antigen
expression; and survival.
Results: All tumor samples were FAK positive compared to normal colonic
mucosa. FAK protein overexpression was seen in 32 out of 80 cases. FAK
protein overexpression did not correlated with tumor histological grade,
stage, Ki-67 positivity or survival.
Conclusions: Raised FAK protein expression was noted by
immunohistochemistry in human colon carcinoma cases. The implication are
discussed. (C) 2003 Elsevier Ltd. All rights reserved