18,338 research outputs found
Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous adiponectin secreted by adipocytes is post-translationally modified into eight different isoforms, as shown by two-dimensional gel electrophoresis. Carbohydrate detection revealed that six of the adiponectin isoforms are glycosylated. The glycosylation sites were mapped to several lysines (residues 68, 71, 80, and 104) located in the collagenous domain of adiponectin, each having the surrounding motif of GXKGE(D). These four lysines were found to be hydroxylated and subsequently glycosylated. The glycosides attached to each of these four hydroxylated lysines are possibly glucosylgalactosyl groups. Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines. These results indicate that full-length adiponectin produced by mammalian cells is functionally active as an insulin sensitizer and that hydroxylation and glycosylation of the four lysines in the collagenous domain might contribute to this activity.link_to_subscribed_fulltex
Avaliação de frutos de tucumã (Astrocaryum sp) oriundos de coletas no estado do PiauÃ, Brasil.
Espécies de tucumã (Astrocaryum sp.) são palmeiras perenes cujos frutos têm potencial econômico como alimento e como matéria prima para o biodiesel mas, ainda são exploradas pelo extrativismo, por falta de estudos básicos. Têm ampla distribuição e, em suas áreas de ocorrência as plantas apresentam variações para maioria das caracterÃsticas. O Objetivo desse trabalho foi caracterizar e avaliar frutos de tucumã oriundos de municÃpios piauiense. Foram utilizados frutos de 19 matrizes de três locais do PiauÃ, Brasil. De cada matriz foram selecionados ao acaso cinco frutos em plena maturação para a avaliação de quinze caracteres. Os dados qualitativos foram analisados em porcentagem e os quantitativos por estatÃstica simples. A maioria dos caracteres apresentou variações consideráveis. Porém, não foram registradas rachaduras, nem sintomas de pragas e doenças
Structural properties of crumpled cream layers
The cream layer is a complex heterogeneous material of biological origin
which forms spontaneously at the air-milk interface. Here, it is studied the
crumpling of a single cream layer packing under its own weight at room
temperature in three-dimensional space. The structure obtained in these
circumstances has low volume fraction and anomalous fractal dimensions. Direct
means and noninvasive NMR imaging technique are used to investigate the
internal and external structure of these systems.Comment: 9 pages, 4 figures, accepted in J. Phys. D: Appl. Phy
Viabilidade econômica do Adlay na alimentação de suÃnos em crescimento e terminação.
bitstream/item/59350/1/CUsersPiazzonDocuments11.pd
Radiative Corrections to the Aharonov-Bohm Scattering
We consider the scattering of relativistic electrons from a thin magnetic
flux tube and perturbatively calculate the order , radiative
correction, to the first order Born approximation. We show also that the second
order Born amplitude vanishes, and obtain a finite inclusive cross section for
the one-body scattering which incorporates soft photon bremsstrahlung effects.
Moreover, we determine the radiatively corrected Aharonov-Bohm potential and,
in particular, verify that an induced magnetic field is generated outside of
the flux tube.Comment: 14 pages, revtex, 3 figure
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