10 research outputs found
Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism
Geochemical distribution and environmental risk assessment of heavy metals in groundwater of an industrial area and its surroundings, Haridwar, India
Assessment of the Pollution Status and Human Health Risk in Soils from an Agricultural Valley in Northwest Mexico
Multidimensional pollution and potential ecological and health risk assessments of radionuclides and metals in the surface soils of a uranium mine in East China
Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria.
Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention because of their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominases revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds