Decision Costs and Welfare Effects of Democratic Voting Rules: An Experimental Analysis

What impact do majority rule and unanimity rule have on welfare and decision costs? According to Buchanan and Tullock ([1962] 1999) the unanimity principle must be regarded as a democratic norm, because it guarantees Pareto-efficient welfare effects. We present experimental results from a public goods game, which demonstrate in contrast to this assumption that majority rule can produce greater welfare effects than unanimity rule. This result suggests a critical revision of theoretical approaches which narrow the legiti­macy of majority rule in this respect

Decision Costs and Welfare Effects of Democratic Voting Rules: An Experimental Analysis

What impact do majority rule and unanimity rule create on welfare and decision costs? According to Buchanan and Tullock ([1962] 1999) the unanimity principle must be regarded as a democratic norm, because it guarantees Pareto-efficient welfare effects. We present experimental results from a public goods game, which demonstrate in contrast to this assumption that majority rule can produce larger welfare effects than unanimity rule. This result suggests a critical revision of theoretical approaches which narrow the legitimacy of majority rule in this respect

Brief Depression Screening with the PHQ-2 Associated with Prognosis Following Percutaneous Coronary Intervention with Paclitaxel-Eluting Stenting

BACKGROUND: Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice. OBJECTIVES: We examined whether the two-item Patient Health Questionnaire (PHQ-2) was associated with adverse events in percutaneous coronary intervention (PCI) patients treated with paclitaxel-eluting stenting (using the continuous score and various cutoffs), overall and by gender. DESIGN: Prospective follow-up study. PARTICIPANTS: Consecutive PCI patients (n=796) seen at a university medical centre. MEASUREMENTS: PHQ-2 at baseline. The study end-point was an adverse event, defined as a combination of death or non-fatal myocardial infarction (MI) at follow-up (mean of 1.4 years). RESULTS: At follow-up, 47 patients had experienced an adverse event. Using the continuous score of the PHQ-2 and the recommended cutoff >= 3, depressive symptoms were not associated with adverse events (ps>0.05). Using a cutoff >= 2, depressive symptoms were significantly associated with adverse events (HR: 1.89; 95% CI: 1.06-3.35) and remained significant in adjusted analysis (HR: 1.90; 95% CI: 1.05-3.44). Depressive symptoms were associated with an increased risk of adverse events in men (HR: 2.69; 95% CI: 1.36-5.32) but not in women (HR: 0.76; 95% CI: 0.24-2.43); these results remained in adjusted analysis. CONCLUSIONS: Depression screening with a two-item scale and a cutoff score of >= 2 was independently associated with adverse events at follow-up. The PHQ-2 is a brief and valid measure that can easily be used post PCI to identify patients at risk for adverse health outcomes

Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control

Missing in Metastasis (MIM), or Metastasis Suppressor 1 (MTSS1), is a highly conserved protein, which links the plasma membrane to the actin cytoskeleton. MIM has been implicated in various cancers, however, its modes of action remain largely enigmatic. Here, we performed an extensive in silico characterisation of MIM to gain better understanding of its function. We detected previously unappreciated functional motifs including adaptor protein (AP) complex interaction site and a C-helix, pointing to a role in endocytosis and regulation of actin dynamics, respectively. We also identified new functional regions, characterised with phosphorylation sites or distinct hydrophilic properties. Strong negative selection during evolution, yielding high conservation of MIM, has been combined with positive selection at key sites. Interestingly, our analysis of intra-molecular co-evolution revealed potential regulatory hotspots that coincided with reduced potentially\ua0pathogenic polymorphisms. We explored databases for the mutations and expression levels of MIM in cancer. Experimentally, we focused on chronic lymphocytic leukaemia (CLL), where MIM showed high overall expression, however, downregulation on poor prognosis samples. Finally, we propose strong conservation of MTSS1 also on the transcriptional level and predict novel transcriptional regulators. Our data highlight important targets for future studies on the role of MIM in different tissues and cancers

Regional and sectoral varieties of capitalism

This study seeks to go beneath the generalizations that constitute characterizations of national economies in order to examine local and sectoral diversity - in particular, forms of capitalist organization at the level of localized sectors. It reports on the findings of research based on detailed case histories of local economies in four different types of production: modernized craft manufacturing (furniture), mass production (motor vehicles), high-technology production (biopharmaceuticals) and high-tech services (television film-making). In each case a local economy in Germany (usually seen counter-factually as an example of a particularly national system) was compared with one elsewhere in Europe: respectively, southern Sweden, Hungary (compared with eastern Germany) and the UK (for two studies). In the analysis, companies act rationally in response to sector-specific challenges, being partly bound by the existing institutional framework that they encounter, but partly acting to alter it. Two possibilities are distinguished and found in the cases. In the first (structurally conservative) case, arrangements of governance in the national innovation and production system prove to be beneficial for the companies and their aim to stand up to international competition. Insofar as national institutions help companies to deal with competition on their markets, they will probably try to preserve these arrangements. In the second (innovative) case, companies turn away from the national context and develop their own local governance structure. If the national institutional structure is seen as not adequate or 'non-fitting' to deal with sectorally specific terms of competition, then the internal and external coordination of companies - in reaction to challenges posed by the market - is likely to deviate from the national structure. In some instances evidence of 'creative incoherence', where local deviation from the national model provides a creative impulse, is found

Behavioral Differences between Collective and Individual Players in the Public Goods Game

Most experiments comparing individual and group behavior find that groups behave more egoistically than individuals. However, most of these studies do not control for the influence of the within-group decision making mechanism which might have an important impact on group behavior. In this paper, we report first results of laboratory experiments comparing individual and group behavior in a public goods game. Groups decide by majority rule. We find that cooperation levels do not differ between groups and individuals. The median player is the most influential group member. We can show that the institutional incentives set by majority rule dominate psychological traits which presumably lead to more selfish group behavior in other experimental settings