324 research outputs found
A trajetĂłria do Programa Nacional de Alimentação Escolar no perĂodo de 2003-2010: relato do gestor nacional
L-alanyl-glutamine pretreatment attenuates acute inflammatory response in children submitted to palatoplasty
Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug-drug or drug-additive interactions, or even to convert oil and liquid drugs into microcrystalline or amorphous powders. A more recent trend focuses on the use of CDs as nanocarriers, a strategy that aims to design versatile delivery systems that can encapsulate drugs with better physicochemical properties for oral delivery. Thus, the aim of this work was to review the applications of the CDs and their hydrophilic derivatives on the solubility enhancement of poorly water soluble drugs in order to increase their dissolution rate and get immediate release, as well as their ability to control (to prolong or to delay) the release of drugs from solid dosage forms, either as complexes with the hydrophilic (e.g. as osmotic pumps) and/ or hydrophobic CDs. New controlled delivery systems based on nanotechonology carriers (nanoparticles and conjugates) have also been reviewed
The Choice of the Best Surgery After Single Level Anterior Cervical Spine Discectomy: A Systematic Review
Cotidiano de mulheres apĂłs contágio pelo HIV/AIDS: subsĂdios norteadores da assistĂŞncia de enfermagem
Planejamento de cardápios para escolas públicas municipais: reflexão e ilustração desse processo em duas capitais brasileiras
Implicações do desenvolvimento econômico no trabalho, ambiente e saúde em comunidades portuárias no Ceará, Brasil
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