The impact of HENRY on parenting and family lifestyle: Exploratory analysis of the mechanisms for change

Background Childhood obesity is a major public health concern. In the UK, a quarter of children are overweight or obese at age five years. Overweight and obese children are more likely to develop serious health issues such as diabetes later in life. Consequently, there is an urgent need for effective, early obesity prevention and intervention. This study investigated the impact of an eight‐week child obesity intervention ‐ HENRY (Health Exercise Nutrition for the Really Young) ‐ designed to help parents with preschool children develop the skills and knowledge needed to improve family lifestyle and wellbeing. We were particularly interested in exploring the potential mechanisms by which HENRY may have a positive impact. Method Focus groups (n=7, total participants = 39) were completed with mothers attending the HENRY programme at one of seven locations across England. They took place within two weeks of programme completion. Follow‐up telephone interviews were completed with a subsample of participants (n=10) between 17 and 21 weeks later. Results Parents consistently reported enhanced self‐efficacy in terms of improved confidence in their ability to encourage healthier behaviours such as eating fruit and increasing physical activity, and improvements to family health behaviours. Many changes were reportedly sustained at follow‐up. Data provided insights into the potential mechanisms that created the conditions for the positive changes. Participants described the importance of mutual support, being listened to by facilitators and encouragement to identify their own ideas. Their comments indicated the success of a solution‐focused, strength‐based, partnership approach to supporting family lifestyle change. Conclusion The results of this study contribute to the body of evidence suggesting that HENRY may have a positive impact on parenting and family lifestyle behaviour. Although data were collected in 2011, the findings contribute to an understanding of the components of effective obesity prevention in young children

Manipulating photon coherence to enhance the security of distributed phase reference quantum key distribution

Distributed-phase-reference (DPR) systems were introduced as a method of decreasing the complexity of quantum key distribution systems for practical use. However, their information-theoretic security has only been proven when the added requirement of block-wise phase randomisation is met. Realisation of this with a conventional approach would result in a cumbersome transmitter, removing any practical advantage held by DPR systems. Here we solve this problem using a light source that allows the coherence between pulses to be controlled on a pulse-by-pulse basis without the need for additional bulky components. The system is modulator-free, does not require a complex receiver, and features an excellent stability without an active stabilisation mechanism. We achieve megabit per second key rates that are almost three times higher than those obtained with the standard Bennet-Brassard 1984 (BB84) protocol

Directly phase-modulated light source

The art of imparting information onto a light wave by optical signal modulation is fundamental to all forms of optical communication. Among many schemes, direct modulation of laser diodes stands out as a simple, robust, and cost-effective method. However, the simultaneous changes in intensity, frequency, and phase have prevented its application in the field of secure quantum communication. Here, we propose and experimentally demonstrate a directly phase-modulated light source which overcomes the main disadvantages associated with direct modulation and is suitable for diverse applications such as coherent communications and quantum cryptography. The source separates the tasks of phase preparation and pulse generation between a pair of semiconductor lasers leading to very pure phase states. Moreover, the cavity-enhanced electro-optic effect enables the first example of subvolt half-wave phase modulation at high signal rates. The source is compact, stable, and versatile, and we show its potential to become the standard transmitter for future quantum communication networks based on attenuated laser pulses

Gray's time-varying coefficients model for posttransplant survival of pediatric liver transplant recipients with a diagnosis of cancer

Transplantation is often the only viable treatment for pediatric patients with end-stage liver disease. Making well-informed decisions on when to proceed with transplantation requires accurate predictors of transplant survival. The standard Cox proportional hazards (PH) model assumes that covariate effects are time-invariant on right-censored failure time; however, this assumption may not always hold. Gray's piecewise constant time-varying coefficients (PC-TVC) model offers greater flexibility to capture the temporal changes of covariate effects without losing the mathematical simplicity of Cox PH model. In the present work, we examined the Cox PH and Gray PC-TVC models on the posttransplant survival analysis of 288 pediatric liver transplant patients diagnosed with cancer. We obtained potential predictors through univariable (P < 0.15) and multivariable models with forward selection (P < 0.05) for the Cox PH and Gray PC-TVC models, which coincide. While the Cox PH model provided reasonable average results in estimating covariate effects on posttransplant survival, the Gray model using piecewise constant penalized splines showed more details of how those effects change over time. © 2013 Yi Ren et al

Best-Practice Criteria for Practical Security of Self-Differencing Avalanche Photodiode Detectors in Quantum Key Distribution

Fast gated avalanche photodiodes (APDs) are the most commonly used single photon detectors for high bit rate quantum key distribution (QKD). Their robustness against external attacks is crucial to the overall security of a QKD system or even an entire QKD network. Here, we investigate the behavior of a gigahertz-gated, self-differencing InGaAs APD under strong illumination, a tactic Eve often uses to bring detectors under her control. Our experiment and modelling reveal that the negative feedback by the photocurrent safeguards the detector from being blinded through reducing its avalanche probability and/or strengthening the capacitive response. Based on this finding, we propose a set of best-practice criteria for designing and operating fast-gated APD detectors to ensure their practical security in QKD

Intensity modulation as a preemptive measure against blinding of single-photon detectors based on self-differencing cancellation

Quantum key distribution is rising as an important cryptographic primitive for protecting the communication infrastructure in the digital era. However, its implementation security is often weakened by components whose behavior deviates from what is expected. Here we analyze the response of a self-differencing avalanche photodiode, a key enabler for high speed quantum key distribution, to intense light shone from a continuous-wave laser. Under incorrect settings, the cancellation entailed by the self-differencing circuitry can make the detector insensitive to single photons. However, we experimentally demonstrate that even in such cases intensity modulation can be used as an effective measure to restore the detector's expected response to the input light.A.K.-S. gratefully acknowledges financial support from Toshiba Research Europe Ltd. and the Engineering and Physical Sciences Research Council (EPSRC) through an Industrial CASE studentship Grant No. NMZE\187 (RG84410)

Setting best practice criteria for self-differencing avalanche photodiodes in quantum key distribution

In recent years, the security of avalanche photodiodes as single photon detectors for quantum key distribution has been subjected to much scrutiny. The most prominent example of this surrounds the vulnerability of such devices to blinding under strong illumination. We focus on self-differencing avalanche photodiodes, single photon detectors that have demonstrated count rates exceeding 1 GCounts/s resulting in secure key rates over 1 MBit/s. These detectors use a passive electronic circuit to cancel any periodic signals thereby enhancing detection sensitivity. However this intrinsic feature can be exploited by adversaries to gain control of the devices using illumination of a moderate intensity. Through careful experimental examinations, we define here a set of criteria for these detectors to avoid such attacks.EPSRC Toshiba Research Europe Lt

Intrinsic mitigation of the after-gate attack in quantum key distribution through fast-gated delayed detection

The information theoretic security promised by quantum key distribution (QKD) holds as long as the assumptions in the theoretical model match the parameters in the physical implementation. The superlinear behaviour of sensitive single-photon detectors represents one such mismatch and can pave the way to powerful attacks hindering the security of QKD systems, a prominent example being the after-gate attack. A longstanding tenet is that trapped carriers causing delayed detection can help mitigate this attack, but despite intensive scrutiny, it remains largely unproven. Here we approach this problem from a physical perspective and find new evidence to support a detector's secure response. We experimentally investigate two different carrier trapping mechanisms causing delayed detection in fast-gated semiconductor avalanche photodiodes, one arising from the multiplication layer, the other from the heterojunction interface between absorption and charge layers. The release of trapped carriers increases the quantum bit error rate measured under the after-gate attack above the typical QKD security threshold, thus favouring the detector's inherent security. This represents a significant step to avert quantum hacking of QKD systems

Between-centre differences and treatment effects in randomized controlled trials: A case study in traumatic brain injury

BACKGROUND: In Traumatic Brain Injury (TBI), large between-centre differences in outcome exist and many clinicians believe that such differences influence estimation of the treatment effect in randomized controlled trial (RCTs). The aim of this study was to assess the influence of between-centre differences in outcome on the estimated treatment effect in a large RCT in TBI. METHODS: We used data from the MRC CRASH trial on the efficacy of corticosteroid infusion in patients with TBI. We analyzed the effect of the treatment on 14 day mortality with fixed effect logistic regression. Next we used random effects logistic regression with a random intercept to estimate the treatment effect taking into account between-centre differences in outcome. Between-centre differences in outcome were expressed with a 95% range of odds ratios (OR) for centres compared to the average, based on the variance of the random effects (tau2). A random effects logistic regression model with random slopes was used to allow the treatment effect to vary by centre. The variation in treatment effect between the centres was expressed in a 95% range of the estimated treatment ORs. RESULTS: In 9978 patients from 237 centres, 14-day mortality was 19.5%. Mortality was higher in the treatment group (OR = 1.22, p = 0.00010). Using a random effects model showed large between-centre differences in outcome (95% range of centre effects: 0.27- 3.71), but did not substantially change the estimated treatment effect (OR = 1.24, p = 0.00003). There was limited, although statistically significant, between-centre variation in the treatment effect (OR = 1.22, 95% treatment OR range: 1.17-1.26). CONCLUSION: Large between-centre differences in outcome do not necessarily affect the estimated treatment effect in RCTs, in contrast to current beliefs in the clinical area of TBI