8 research outputs found
acute effects of mercuric chloride on intracellular GSH levels and mercury distribution in the fish Oreochromis aureus
10.1007/BF01881036Bulletin of Environmental Contamination and Toxicology402178-184BECT
Strain difference of cadmium-induced testicular toxicity in inbred Wistar-Imamichi and Fischer 344 rats
Previously, we reported that Wistar-Imamichi (WI) rats are highly resistance to cadmium (Cd)-induced lethality and hepatotoxicity compared to Fischer 344 (F344) rats. Since the testes are one of the most sensitive organs to acute Cd toxicity, we examined possible strain-related differences in Cd-induced testicular toxicity between inbred WI and F344 rats. Rats were treated with a single dose of 0.5, 1.0 or 2.0 mg Cd/kg, as CdCl2, sc and killed at 24 h later. Cd at doses of 1.0 and 2.0 mg/kg induced severe testicular hemorrhage, as assessed by pathologically and testis hemoglobin content, in F344 rats, but not WI rats. After Cd treatment (2.0 mg/kg), testicular Cd content was significantly lower in WI rats than in the F344 rats, indicating a toxiokinetic mechanism for the observed strain difference. Thus, the remarkable resistance to Cd-induced testicular toxicity in WI rats is associated, at least in part, with lower testicular accumulation of Cd. When zinc (Zn; 10 mg/kg, sc) was administered in combination with Cd (2.0 mg/kg) to F344 rats, the Cd-induced increase in testicular hemoglobin content, indicative of hemorrhage, was significantly reduced. Similarly, testicular Cd content was significantly decreased with Zn co-treatment compared to Cd treatment alone. Thus, it can be concluded that testicular Cd accumulation partly competes with Zn transport systems and that these systems may play an important role in the strain-related differences in Cd-induced testicular toxicity between WI and F344 rats