Control vs. Creativity

They’re eternal questions in business: Does management control kill creativity? How can organizations manage efficiency within innovating processes? Do control and creativity call for a balance within processes of innovation—or is balancing a bad idea? The answers to these questions are probably bedeviling entrepreneurs and executives everywhere around the world. While a controlled working environment has its advantages, too much control can hamper the creativity, as well as the ability to innovate, that leads to new products and to growth and profitability. The article addresses these issues by offering insights from a medium-sized company in the fashion industry that has used formal and informal control tools to manage its need for both standardization and innovation

4,5-Functionalized 6-phenyl-3(2H)pyridazinones: synthesis and evaluation of antinociceptive activity

A series of 2-substituted 4,5-functionalized 6-phenyl-3(2H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse abdominal constriction model. Single dose studies showed that compounds 11, 18a and 23 were more active than the reference drug, Emorfazone, in inhibiting the effects of the noxious chemical stimulus, p-phenylquinone. Subsequent dose-response studies revealed 18a to be almost seven-fold more potent than Emorfazone

Novel 3-arylamino- and 3-cycloalkylamino-5,6-diphenylpyridazines active as ACAT inhibitors

A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3-(cyclo)alkylamino-5,6-diphenyl-pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3-alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it

5,6-diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

Alkyl-5,6-diphenylpyridazine derivatives combining several main features of ACAT inhibitors, such as a long alkyl side chain linked to a heterocycle and the o-diphenyl system, were synthesized and tested. Moreover, modeling studies on representative terms were performed. Some compounds displayed ACAT inhibition in the micromolar range, both on the enzyme isolated from rat liver microsomes and in cell-free homogenate of murine macrophages

5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the ACAT inhibitor 5,6-diphenyl-3-alkylaminopyridazines

A series of dinitro and monoamino-mononitro analogues of the 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features