GGE biplot for stability and adaptability in cashew tree clones = GGE Biplot para estabilidade e adaptabilidade em clones de cajueiro

The interaction genotype versus environment makes it difficult the genetic improvement of the species for the selection of more adapted and stable genotypes. Thus, the objective of this work was to evaluate new clones of early dwarf cashews, in terms of stability and adaptability, employing the GGE biplot methodology. The experimental design was based on randomized blocks with four replications and 15 treatments (different clones). The variables evaluated were cashew production per plant (PCP), average mass of chashew (MMC) and early harvest (PRE). The clones G1 and G3 for MMC, G15, G2, G14 and G8 for PRE and G3, G10 and G2 for PCP approached the ideotype; the clones identified as top for each characteristic were not coincident; the majority of the clones were stable for MMC, while for PRE and PCP were not stable; the clone G4 had the best average in PRE, but with low stability; in the GGE biplot the environments A3 for MMC, A4 to PRE and A5 for PCP were the most discriminating; all environments had greater contribution in the differentiation of clones in PRE and MMC, for PCP were the environments A4 and A5; in relation at the average representativeness the environments A1 in MMC and A2 for PRE and PCP stood out. = A interação genótipos versus ambientes dificulta o melhoramento genético das espécies para a seleção de genótipos adaptados e estáveis. Assim, objetivou-se com este trabalho avaliar novos clones de cajueiro-anão precoce, quanto a estabilidade e adaptabilidade, empregando a metodologia Biplot GGE. O delineamento experimental foi em blocos casualizados com quatro repetições e 15 tratamentos (diferentes clones). As variáveis avaliadas foram produção de castanha por planta (PCP), massa média de castanha (MMC) e precocidade de colheita (PRE). Os clones G1 e G3 para MMC; G15, G2, G14 e G8 para PRE e, G3, G10 e G2 para PCP se aproximaram do ideótipo; os clones identificados como superiores para cada característica não foram coincidentes; a maioria dos clones foram estáveis para MMC, enquanto que para PRE e PCP não foram estáveis; o clone G4 teve a melhor média em PRE, mas com baixa estabilidade; no GGE Biplot os ambientes A3 para MMC, A4 para PRE e A5 para PCP foram os mais discriminadores; todos os ambientes tiveram maior contribuição na diferenciação dos clones em PRE e MMC, para PCP foram os ambientes A4 e A5 e; em relação a representatividade média os ambientes A1 em MMC e A2 para PRE e PCP se destacaram

GGE biplot for stability and adaptability in cashew tree clones

The interaction genotype versus environment makes it difficult the genetic improvement of the species for the selection of more adapted and stable genotypes. Thus, the objective of this work was to evaluate new clones of early dwarf cashews, in terms of stability and adaptability, employing the GGE biplot methodology. The experimental design was based on randomized blocks with four replications and 15 treatments (different clones). The variables evaluated were cashew production per plant (PCP), average mass of chashew (MMC) and early harvest (PRE). The clones G1 and G3 for MMC, G15, G2, G14 and G8 for PRE and G3, G10 and G2 for PCP approached the ideotype; the clones identified as top for each characteristic were not coincident; the majority of the clones were stable for MMC, while for PRE and PCP were not stable; the clone G4 had the best average in PRE, but with low stability; in the GGE biplot the environments A3 for MMC, A4 to PRE and A5 for PCP were the most discriminating; all environments had greater contribution in the differentiation of clones in PRE and MMC, for PCP were the environments A4 and A5; in relation at the average representativeness the environments A1 in MMC and A2 for PRE and PCP stood out

NUOVE RICERCHE SUL SITO DEL BRONZO DI PORTELLA NELL'ISOLA DI SALINA

ATTI DELLA XXXV RIUNIONE SCIENTIFICA DELL'ISTITUTO ITALIANO DI PREISTORIA E PROTOSTORI

Phase II study of gemcitabine, oxaliplatin, and cetuximab in advanced pancreatic cancer

Little progress has been made in the treatment of pancreatic cancer (PC). This study evaluated the clinical activity of gemcitabine, oxaliplatin, and cetuximab (GOC) in patients with locally advanced or metastatic PC. The study primary endpoint was progression-free survival (PFS). Eligible, chemotherapy-naive PC patients were treated with gemcitabine (1000 mg/m(2) over 100 min) on day 1, oxaliplatin (100 mg/m(2)) on day 2, every 2 weeks, and weekly cetuximab, (loading dose of 400 mg/m(2) on cycle 1 day 1 and 250 mg/m(2) thereafter). It was expected that GOC treatment would extend the median PFS from 5.8 to 7.54 months, a relative increase of 30%, compared with gemcitabine and oxaliplatin (historical control). A total of 41 evaluable patients were enrolled. The overall response rate was 24%. Median PFS time was 6.9 months and median overall survival (OS) was 11.3 months. Patients with locally advanced disease had longer median PFS (12.4 vs. 4.7 mo) and OS (15.7 vs. 6.4 mo) compared with patients with metastatic disease. The most common grade 3 to 4 toxicities included neutropenia (32%), infection (with normal or grade 1 to 2 neutropenia, in 24%), neuropathy (17%), fatigue (15%), and rash (7%). Five patients (12%) discontinued study treatment without evidence of progression. Rash was not a significant prognostic factor affecting PFS or OS. GOC is a feasible combination with an acceptable toxicity profile. However, GOC did not significantly extend PFS in the overall patient population to consider it for further development