108 research outputs found
Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes
Metformin is the first-line treatment for type 2 diabetes (T2D). Although widely prescribed, the glucose-lowering mechanism for metformin is incompletely understood. Here, we used a genome-wide association approach in a diverse group of individuals with T2D from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial to identify common and rare variants associated with HbA 1c response to metformin treatment and followed up these findings in four replication cohorts. Common variants in PRPF31 and CPA6 were associated with worse and better metformin response, respectively (P < 5 3 10 26 ), and meta-analysis in independent cohorts displayed similar associations with metformin response (P = 1.2 3 10 2 8 and P = 0.005, respectively). Previous studies have shown that PRPF31(+/2) knockout mice have increased total body fat (P = 1.78 3 10 26 ) and increased fasted circulating glucose (P = 5.73 3 10 26 ). Furthermore, rare variants in STAT3 associated with worse metformin response (q <0.1). STAT3 is a ubiquitously expressed pleiotropic transcriptional activator that participates in the regulation of metabolism and feeding behavior. Here, we provide novel evidence for associations of common and rare variants in PRPF31, CPA6, and STAT3 with metformin response that may provide insight into mechanisms important for metformin efficacy in T2D
Morphogenetic and structural characteristics of tillers of guinea grass of different age and grazing severities
Implantação de pastagens sob sistema monocultivo e integrado com lavoura utilizando biofertilizante de cama de aviário como adubação de cobertura
Desempenho agronômico de plantas de cobertura usadas na proteção do solo no período de pousio
Formas de uso do solo no inverno e sua relação com a infestação de plantas daninhas em milho (Zea mays) cultivado em sucessão
Crescimento de raízes dos capins aruana e tanzânia submetidos a duas doses de nitrogênio
A grazing height target to minimize tiller stem elongation rate in annual ryegrass swards
Mineralização e efeitos de biocarvão de cama de frangosobre a capacidade de troca catiônica do solo
- …