23 research outputs found
Secondary adrenocortical insufficiency: Avoiding potentially fatal pitfalls in diagnosis and treatment
Use of Aminohydroxypropylidene Bisphosphonate (Ahprbp, Apd) for the Treatment of Hypercalcemia in Patients with Renal Impairment
Aminohydroxypropylidene bisphosphonate (ACPrBP, 'APD') is a relatively new bisphosphonate which has been shown to be effective for control of hypercalcemia due to a variety of causes. Renal impairment has been reported following the use of other bisphosphonates and pre-existing renal impairment has been regarded as a contraindication to the use of AHPrBP. We report the successful use of intravenous AHPrBP to control hypercalcemia in three patients with renal impairment, one of whom was dialysis-dependent. No significant side effects were noted; in particular, there was no further deterioration in renal function. Intravenous AHPrBP may be a safe and effective agent for the control of hypercalcemia in patients with renal impairment
Short synacthen test versus insulin stress test for the assessment of the hypothalmo-pituitary axis: Controversy revisited again
Crh-Mediated Pituitary-Adrenal Responses Are Inhibited by Nifedipine in Humans
SUSTAINED CRH-stimulated ACTH release in vitro depends on Ca2+ influx and is inhibited 30-40%, but not delayed, by dihydropyridine Ca2+ channel blockers. In five normal humans, we found that nifedipine pretreatment reduced integrated ACTH responses to the CRH-mediated stimulus of fenfluramine by 28% and cortisol responses by 34%, results comparable with those from in vitro reports. Nifedipine did not alter the timing of peak hormonal responses. We conclude that (1) in humans, nifedipine inhibits ACTH release by fenfluramine by blocking Ca2+ influx via L-type channels in corticotrophs; (2) the magnitude of fenfluramine-stimulated CRH release is probably unaltered by nifedipine and (3) because the timing is unaltered, nifedipine does not affect the rate of CRH delivery to the corticotroph
Secondary adrenocortical insufficiency: avoiding potentially fatal pitfalls in diagnosis and treatment
Altered Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Myotonic-Dystrophy - Invivo Evidence for Abnormal Dihydropyridine-Insensitive Calcium-Transport
In persons with myotonic dystrophy (DM), the ACTH response to CRH is greater than normal, while it is delayed in response to arginine vasopressin. Since influx of extracellular Ca2+ ions is a common step in signal transduction by both of these secretagogues, an abnormality of cellular Ca2+ transport may underlie the disturbances of hypothalamic-pituitary-adrenal axis function in this condition
The Effect of Desipramine On Basal and Naloxone-Stimulated Cortisol Secretion in Humans - Interaction of 2 Drugs Acting On Noradrenergic Control of Adrenocorticotropin Secretion
Desipramine (DMI), a tricyclic antidepressant and norepinephrine (NE) reuptake blocker, is reported to induce ACTH and cortisol release acutely in humans, probably by facilitating central NE neurotransmission. Tricyclic antidepressant therapy, including DMI, normalizes the ACTH and cortisol hypersecretion that often accompanies depression. The mechanism of hypothalamic-pituitary-adrenal (HPA) axis inhibition by DMI in humans is unknown. In rats, DMI reduces the activity of the locus ceruleus, a major source of NE innervation of the hypothalamic paraventricular nucleus, the site of CRH neurons. Naloxone induces ACTH and cortisol release in humans through a noradrenergic-mediated mechanism and a probable consequent stimulation of hypothalamic CRH release
Alprazolam Attenuates Vasopressin-Stimulated Adrenocorticotropin and Cortisol Release - Evidence for Synergy Between Vasopressin and Corticotropin-Releasing Hormone in Humans
Alprazolam (APZ), a triazolobenzodiazepine with unique clinical utility, has potent inhibitory effects on the human hypothalamic-pituitary-adrenal axis. Because APZ inhibits CRH secretion from isolated rat hypothalami and inhibits the probable CRH-mediated effect of naloxone on ACTH release, it is likely APZ acts as an inhibitor of hypothalamic CRH release in humans. The two principal physiological ACTH secretagogues are CRH and arginine vasopressin (AVP)
Alprazolam Blocks the Naloxone-Stimulated Hypothalamo-Pituitary-Adrenal Axis in Man
Alprazolam (APZ) is a benzodiazepine with unique antidepressant activity for a drug of its class. There is some evidence of inhibition of the unstimulated hypothalamo-pituitary-adrenal axis by APZ which may be important in its therapeutic action, and could be detrimental in APZ-treated subjects who encounter stressful stimuli