Use of Aminohydroxypropylidene Bisphosphonate (Ahprbp, Apd) for the Treatment of Hypercalcemia in Patients with Renal Impairment

Abstract

Aminohydroxypropylidene bisphosphonate (ACPrBP, 'APD') is a relatively new bisphosphonate which has been shown to be effective for control of hypercalcemia due to a variety of causes. Renal impairment has been reported following the use of other bisphosphonates and pre-existing renal impairment has been regarded as a contraindication to the use of AHPrBP. We report the successful use of intravenous AHPrBP to control hypercalcemia in three patients with renal impairment, one of whom was dialysis-dependent. No significant side effects were noted; in particular, there was no further deterioration in renal function. Intravenous AHPrBP may be a safe and effective agent for the control of hypercalcemia in patients with renal impairment