6 research outputs found
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
A comparison of behavioral and psychological characteristics of patients opting for surgical and conservative treatment for morbid obesity
Macromolecular modeling and design in Rosetta: recent methods and frameworks
The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability. Rosetta is available at .This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta