Archaeological excavation : Skelhorne Street Phase 2, Liverpool

In April 2017, Salford Archaeology was commissioned by Nexus-Heritage to carry out an archaeological excavation of a well and potential workers housing at Skelhorne Street and Bolton Street, Liverpool (centred on NGR 335075 390430). The excavation of the well was carried out on the 30th and 31st of March 2017, following an initial archaeological evaluation Salford Archaeology in January 2017. During the evaluation the presence of ACMs within upper levelling layers meant that the northern end of the site could not be adequately evaluated. Following remediation of this area a trench was excavated across it by Nexus-Heritage during April 2017. The well was machine stripped to its upper level after which it was hand excavated to a depth of c. 1.5m. Following this a 5m square box was excavated 1.5m into the bedrock allowing safe access to hand excavate a further 1.5m of the well. The well was found to be 0.98m in diameter and 7m deep. Its tool marks were consistent with a 19th century feature, serving housing that was built in the early 19th century and appears on the 1848 OS mapping. The fill suggested that it was infilled during the early 20th century when the housing was demolished. The northern trench revealed that the ground reduction observed across the southern half of the site during the evaluation continued across the northern part of the site and no features or structures of archaeological significance remained within the area. The results obtained during the excavations suggested that no further investigation was merited

Reaction time and incident cancer: 25 years of follow-up of study members in the UK Health and Lifestyle Survey

<b>Objectives</b><p></p> To investigate the association of reaction time with cancer incidence.<p></p> <b>Methods</b><p></p> 6900 individuals aged 18 to 94 years who participated in the UK Health and Lifestyle Survey in 1984/1985 and were followed for a cancer registration for 25 years.<p></p> <b>Results</b><p></p> Disease surveillance gave rise to 1015 cancer events from all sites. In general, there was essentially no clear pattern of association for either simple or choice reaction time with cancer of all sites combined, nor specific malignancies. However, selected associations were found for lung cancer, colorectal cancer and skin cancer.<p></p> <b>Conclusions</b><p></p> In the present study, reaction time and its components were not generally related to cancer risk

Computer simulations of iron in magnesium silicate perovskite

We use atomistic computer simulation techniques to investigate the site partitioning of iron in (Mg,Fe)SiO_{3} perovskites. Our calculations predict that the most energetically favourable reaction for iron substitution will be a direct exchange of Fe^{2+} for Mg^{2+}. Substitution of Fe into the octahedral site and Si into the 8–12 fold coordinated site, as proposed by Jackson et al. [1987], is predicted to be extremely unlikely

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.

Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), the most extensively studied and best validated tracer. PIB binds specifically to fibrillar beta-amyloid (Abeta) deposits, and is a sensitive marker for Abeta pathology in cognitively normal older individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). PIB-PET provides us with a powerful tool to examine in vivo the relationship between amyloid deposition, clinical symptoms, and structural and functional brain changes in the continuum between normal aging and AD. Amyloid imaging studies support a model in which amyloid deposition is an early event on the path to dementia, beginning insidiously in cognitively normal individuals, and accompanied by subtle cognitive decline and functional and structural brain changes suggestive of incipient AD. As patients progress to dementia, clinical decline and neurodegeneration accelerate and proceed independently of amyloid accumulation. In the future, amyloid imaging is likely to supplement clinical evaluation in selecting patients for anti-amyloid therapies, while MRI and FDG-PET may be more appropriate markers of clinical progression

Introducing doubt in Bayesian model comparison

There are things we know, things we know we dont know, and then there are things we dont know we dont know. In this paper we address the latter two issues in a Bayesian framework, introducing the notion of doubt to quantify the degree of (dis)belief in a model given observational data in the absence of explicit alternative models. We demonstrate how a properly calibrated doubt can lead to model discovery when the true model is unknown

Intelligent protocol adaptation for enhanced medical e-collaboration

Copyright @ 2003 AAAIDistributed multimedia e-health applications have a set specific requirements which must be taken into account effective use is to be made of the limited resources provided by public telecommunication networks. Moreover, there an architectural gap between the provision of network-level Quality of Service (QoS) and user requirements of e-health applications. In this paper, we address the problem bridging this gap from a multi-attribute decision-making perspective in the context of a remote collaborative environment for back pain treatment. We propose intelligent mechanism that integrates user- related requirements with the more technical characterisation Quality of Service. We show how our framework is capable of suggesting appropriately tailored transmission protocols, by incorporating user requirements in the remote delivery e-health solutions

Collaborative learning: a connected community approach

Collaborative Learning in group settings currently occurs across a substantial portion of the UK Higher Education curriculum. This style of learning has many roots including: Enterprise in Higher Education, Action Learning and Action Research, Problem Based Learning, and Practice Based Learning. As such our focus on Collaborative Learning development can be viewed as an evolutionary. This collaborative and active group learning provides the foundation for what can be collectively called connectivist ‘Learning Communities’. In this setting a primary feature of a ‘Learning Community’ is one that carries a responsibility to promote one another’s learning. This paper will outline a developmental collaborative learning approach and describe a supporting software environment, known as the Salford Personal Development Environment (SPDE), that has been developed and implemented to assist in delivering collaborative learning for post graduate and other provision. This is done against a background of much research evidence that group based activity can enhance learning. These findings cover many approaches to group based learning and over a significant period of time. This paper reports on work-in-progress and the features of the environment that are designed to help promote individual and group or community learning that have been influenced by the broad base of research findings in this area

Intelligent multimedia transmission for back pain treatment

Copyright @ 2002 EUNITERemote, multimedia-based, collaboration in back pain treatment is an option which only recently has come to the attention of clinicians and IT providers. The take up of such applications will inevitably depend on their ability to produce an acceptable level of service over congested and unreliable public networks However, although the problem of multimedia application-level performance is closely linked to both the user perspective of the experience as well as to the service provided by the underlying network, it is rarely studied from an integrated viewpoint. To alleviate this problem in the context of a multimedia application, a method is proposed in this paper for obtaining a priority order of low-level Quality of Service parameters, which would ensure that user-level Quality of Perception is maintained at an optimum level. Thus we present an approach that integrates technical concerns with user perceptual considerations for intelligent decision-making in the construction of tailor-made multimedia communication protocols. The proposed approach, based on multicriteria decision making, incorporates not only classical networking considerations, but, indeed, user preferences as well. Moreover, our approach also opens the possibility for such protocols to dynamically adapt based on a changing operating environment and user preferences