Southeast Asian industrialisation and the changing global production system

The diversion of foreign direct investment (FDI) flows into developing Asia, from Southeast Asia to China, has renewed doubts about whether Southeast Asia's traditional reliance on FDI has left the region without the local capabilities required to sustain the region's long-term competitiveness. Southeast Asia's industrialisation has involved deepening integration into international production networks, comprising internal exchanges between multinational corporations (MNCs) and their subsidiaries, affiliates and subcontractors. While indigenous industry has been secondary to Southeast Asian industrialisation, this paper highlights three elements of local technological accumulation and clustering within foreign-dominated export industries: production deepening, co-location of design, engineering and R&D with off-shore manufacturing, and the spatial clustering of MNCs in particular industry segments. Southeast Asian governments have responded to these trends by broadening investment promotion from manufacturing to business services and regional headquarters operations, by targeting incentives and infrastructure development to foster industrial clusters, and by invigorating technical support programmes for local small and medium-sized enterprises (SMEs) in supporting industries. Taken together, these trends suggest that Southeast Asia will remain an important site within multinationals' international production networks

Water and Sodium in Heart Failure: A Spotlight on Congestion

Despite all available therapies, the rates of hospitalization and death from heart failure (HF) remain unacceptably high. The most common reasons for hospital admission are symptoms related to congestion. During hospitalization, most patients respond well to standard therapy and are discharged with significantly improved symptoms. Post-discharge, many patients receive diligent and frequent follow-up. However, rehospitalization rates remain high. One potential explanation is a persistent failure by clinicians to adequately manage congestion in the outpatient setting. The failure to successfully manage these patients post-discharge may represent an unmet need to improve the way congestion is both recognized and treated. A primary aim of future HF management may be to improve clinical surveillance to prevent and manage chronic fluid overload while simultaneously maximizing the use of evidence-based therapies with proven long-term benefit. Improvement in cardiac function is the ultimate goal and maintenance of a “dry” clinical profile is important to prevent hospital admission and improve prognosis. This paper focuses on methods for monitoring congestion, and strategies for water and sodium management in the context of the complex interplay between the cardiac and renal systems. A rationale for improving recognition and treatment of congestion is also proposed