43 research outputs found
Reverse micelle-loaded lipid nanocarriers: A novel drug delivery system for the sustained release of doxorubicin hydrochloride
Get PDFIn this study, we are pioneering new nanotechnology for the encapsulation of anticancer drugs (doxorubicin (DOX) and/or docetaxel (DOCE)), whatever their solubility and water affinity. The purpose of this study is to highlight the potential of this recently patented technology, by carrying out a thorough physicochemical characterisation of these multiscaled nanocarriers, followed by the study of an encapsulation and release model of hydrophilic anticancer drug. The formulation process is based on a low-energy nano-emulsification method and allows the generation of a structure composed of oil-based nanocarriers loaded with reverse micelles. Thanks to this, hydrophilic contents can be solubilised in the oily core of this kind of nano-emulsion along with lipophilic content. The results emphasise some original structure particularities due to the multistep formulation process, and the diffusion-based behaviour revealed for the DOX release profile that is shown to be intimately linked to the morphology of the particles
Beneficiamento pós-colheita de lima ácida 'Tahiti' afeta sua qualidade e conservação
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State-to-state charge exchange cross sections in high-velocity asymmetric and near-symmetric collisions at 400 MeV Fe ions
No full textTarget nuclear charge dependence of 1s2 1s2p and 1s2 1s3p excitation cross sections of Fe projectiles in the intermediate velocity range
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Electron capture from the krypton M-shell by MeV protons
No full textAn experimental and theoretical study of electron capture by protons from a krypton gas jet target in the energy range 2-3 MeV is performed. A comparison of experimental data with the Continuum Distorted Wave theory reveals that electrons are captured predominantly from the 3d subshell of krypton. The role of the initial electronic angular momentum in electron capture is discussed.La capture électronique dans un jet gazeux de krypton par des protons de 2 à 3 MeV est étudiée expérimentalement et théoriquement. La comparaison des données expérimentales avec la théorie CDW (« Continuum Distorted Waves » ou « Ondes Continues Déformées ») révèle que la capture a lieu préférentiellement depuis la sous-couche 3d du krypton. Une analyse est faite du rôle joué par le moment orbital électronique initial dans le processus de capture électronique
Production of projectile and target K x-rays by single and multiple electron-capture in collisions of Si and Si ions with argon atoms at 4.5 and 5.5 MeV/amu
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