ReefTemp Next Generation: a new operational system for monitoring reef thermal stress

The expected increase in the frequency of mass coral bleaching under climate change underlines the importance of thermal stress monitoring systems for coral reef management. ReefTemp Next Generation (RTNG) is a sophisticated remote sensing application designed to operationally monitor the ocean temperatures that can lead to coral bleaching across the Great Barrier Reef. Products are derived from state-of-the-art satellite data; and newly calculated climatologies and management thresholds for bleaching are presented. RTNG is a key component of the Great Barrier Reef Marine Park Authority's Early Warning System, which informs management action and response strategies

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis.

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are associated with intellectual disability, but the pathogenic mechanism remains obscure. Here, we characterize 31 individuals with de novo missense variants in CERT1. Several variants fall into a previously uncharacterized dimeric helical domain that enables CERT homeostatic inactivation, without which sphingolipid production goes unchecked. The clinical severity reflects the degree to which CERT autoregulation is disrupted, and inhibiting CERT pharmacologically corrects morphological and motor abnormalities in a Drosophila model of the disease, which we call ceramide transporter (CerTra) syndrome. These findings uncover a central role for CERT autoregulation in the control of sphingolipid biosynthetic flux, provide unexpected insight into the structural organization of CERT, and suggest a possible therapeutic approach for patients with CerTra syndrome

Ciclones em Superfície nas Latitudes Austrais: Parte I - Revisão Bibliográfica

Resumo Com o objetivo de organizar o conhecimento sinótico sobre ciclones em superfície em latitudes austrais, este trabalho (o primeiro de um conjunto de dois) apresenta uma síntese das principais características de quatro tipos de ciclones: extratropical do tipo Bjerknes e Solberg, extratropical do tipo Shapiro e Keyser, tropical e subtropical. Ao longo do texto são apresentados modelos conceituais bem como os mecanismos de ciclogênese, intensificação e ciclólise de cada tipo de ciclone. As principais diferenças entre os quatros tipos de ciclones em superfície estão nas estruturas horizontais e verticais dos campos de temperatura e vorticidade relativa