76 research outputs found
Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents
Anålise da adaptabilidade e estabilidade de produção em ensaios regionais de feijoeiro para o Estado de São Paulo
Genotype-environment interaction in common bean cultivars with carioca grain, recommended for cultivation in Brazil in the last 40 years
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13âinduced tissue responses and apoptosis
Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity. Although YKL-40 is expressed in exaggerated quantities and correlates with disease activity in asthma and many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined. We describe the generation and characterization of BRP-39â/â mice, YKL-40 transgenic mice, and mice that lack BRP-39 and produce YKL-40 only in their pulmonary epithelium. Studies of these mice demonstrated that BRP-39â/â animals have markedly diminished antigen-induced Th2 responses and that epithelial YKL-40 rescues the Th2 responses in these animals. The ability of interleukin13 to induce tissue inflammation and fibrosis was also markedly diminished in the absence of BRP-39. Mechanistic investigations demonstrated that BRP-39 and YKL-40 play an essential role in antigen sensitization and immunoglobulin E induction, stimulate dendritic cell accumulation and activation, and induce alternative macrophage activation. These proteins also inhibit inflammatory cell apoptosis/cell death while inhibiting Fas expression, activating protein kinase B/AKT, and inducing Faim 3. These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders
Teores de antocianinas, fenĂłis totais, taninos e ĂĄcido ascĂłrbico em uva 'bordĂŽ' sobre diferentes porta-enxertos
Prevalence of overweight preschool children in public day care centers: a cross-sectional study
PrevalĂȘncia de excesso de peso e obesidade abdominal, segundo parĂąmetros antropomĂ©tricos, e associação com maturação sexual em adolescentes escolares
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