11 research outputs found
Potencial antimicrobiano de extratos de plantas na inibição de leveduras do gĂȘnero Candida
The increase in the resistance to antimicrobial drugs in use has attracted the attention of the scientific community, and medicinal plants have been extensively studied as alternative agents for the prevention of infections. The Candida genus yeast can become an opportunistic pathogen causing disease in immunosuppressive hosts. The purpose of this study was to evaluate dichloromethane and methanol extracts from Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum and Syzygium cumini against Candida species through the analysis of Minimum Inhibitory Concentration (MIC). Results presented activity of these extracts against Candida species, especially the methanol extract.Devido ao aumento da resistĂȘncia aos antimicrobianos em uso, as plantas medicinais tĂȘm sido intensamente estudadas como agentes alternativos para a prevenção de doenças e infecçÔes. A levedura do gĂȘnero Candida, por ser um patĂłgeno oportunista, tem sua virulĂȘncia aumentada ao adquirir resistĂȘncia aos antifĂșngicos, desencadeando doenças, principalmente em hospedeiros imunossuprimidos. O propĂłsito deste trabalho foi avaliar os extratos diclorometano e metanol das plantas Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum e Syzygium cumini contra linhagens do gĂȘnero Candida atravĂ©s dos testes de Concentração InibitĂłria MĂnima (CIM). Os resultados demonstraram atividade dos extratos sobre as espĂ©cies de Candida, particularmente o extrato metanol.10651068Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP
Pro-inflammatory Analysis of Macrophages in Contact with Titanium Particles and Porphyromonas gingivalis
Antimicrobial potential of some plant extracts against Candida species
The increase in the resistance to antimicrobial drugs in use has attracted the attention of the scientific community, and medicinal plants have been extensively studied as alternative agents for the prevention of infections. The Candida genus yeast can become an opportunistic pathogen causing disease in immunosuppressive hosts. The purpose of this study was to evaluate dichloromethane and methanol extracts from Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum and Syzygium cumini against Candida species through the analysis of Minimum Inhibitory Concentration (MIC). Results presented activity of these extracts against Candida species, especially the methanol extract
Sexual Dimorphism on Cytokines Expression in the Temporomandibular Joint: The Role of Gonadal Steroid Hormones
Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior (CAPES)Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Temporomandibular joint pain-related conditions are generally characterized by local inflammation; however, little studies have focused on the role of gonadal hormones in the expression of inflammatory mediators, such as cytokines. Therefore, we asked whether gonadal steroid hormones affect formalin-induced cytokines expression in the rat temporomcandibular joint. The expression of tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta, and cytokine-induced neutrophil chemoattractant (CINC)-1 was significantly higher in males than in diestrus and proestrus females and was decreased by orchiectomy and restored by testosterone replacement. The expression of IL-6 was significantly higher in diestrus and proestrus females than in males, and was decreased by ovariectomy and restored by estradiol or progesterone administration. We conclude that testosterone increases the expression of TNF-alpha, IL-1 beta and CINC-1, and estradiol and progesterone increase the expression of IL-6. New clinical approaches based on inhibition of pro-inflammatory mediators are starting to supplant traditional immunosuppressive therapies and gonadal hormones may influence their effectiveness or clinical dosage.345487498Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior (CAPES)Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior (CAPES)Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP