Diarrhea due to Cryptosporidium parvum in immunocompromised and immunocompetent patients in Khartoum State

Objective: The objective of this study is to search for Cryptosporidium parvum in Sudanese immunocompromised and immunocompetent patients presenting with diarrhea.Methods: Two hundred and thirteen stool specimens were collected from different groups of patients presenting with diarrhea and healthy control (immunocompromised: 78; immunocompetent: 90; Control: 45).The immunocompromised group included 25 HIV positive patients, 27 tuberculosis patients, 11 patients with renal failure and 15 patients receiving immunosuppressive chemotherapy. Antigen ELISA was performed to detect the presence of the parasite in stool. Positive specimens were examined by the modified ZN stain to look for the oocyst of C.parvum.Result: Seventy one of the immunocompromised patients (91.0%), twenty nine of immunocompetent patients (32.2 %) and ten of the control group (22.2%) were found to be positive for C.parvum. A significant difference was noticed between the immunocompromised patients and the other groups (