The Swedish Adoption Twin Study of Aging: An Update

AbstractThe Swedish Adoption/Twin Study of Aging (SATSA) is a longitudinal program of research in gerontological genetics which is currently in its fifth year. The base population is comprised of 351 pairs of twins reared apart and 407 matched control pairs of twins reared together who responded to a questionnaire (Q1) in 1984. Two additional stages of SATSA have recently been completed: a longitudinal follow-up questionnaire mailed out in 1987 (Q2) and extensive in-person testing (IPT1) which included a health examination and cognitive battery. A second wave of IPT was started in January 1989. A summary of some of the major findings from Q1 and a description of IPT1 are reported.</jats:p

Coming to terms with heritability

The complex mechanisms of heredity are little appreciated by non-specialists, in some measure, because of misunderstandings that are perpetuated when words used for technical terms have other, more widely understood, folk meanings. When a word has both technical and folk meanings, it is the responsibility of the specialist to avoid promoting confusion by either using extremely cautious and precise language when using the term or, in cases when confusion is inevitable, abandoning the term in favor of one without a widely understood folk meaning. The study of heredity is beset by such confusion, and the term heritability appears to be at the heart of some of the confusion. In this article, I discuss both the technical and folk meanings of heritability and examine the bridge between them. By continuing to use the term heritability, we risk promulgating serious misunderstanding about the workings of heredity, therefore I suggest selectability as an alternative term to avoid such pitfalls.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42804/1/10709_2005_Article_BF02259512.pd

Genetics and behavioral medicine

Genetics has substantial relevance to behavioral medicine. A rapidly growing body of evidence indicates the influence of genetics on health and disease and on the behavioral factors related to them. The model of quantitative genetics provides a general interpretational scheme for this burgeoning field. The model focuses on variability and a major research objective is the decomposition of observed individual differences into portions attributable to various types of genetic and environmental sources of variability. This approach emphasizes the coaction of genes and environments and stands in sharp contrast to the archaic view that places nature and nurture in opposition. Some relevant examples are given in this first article to illustrate the general analytic process. A detailed application to cardiovascular health and disease is provided in the second article, and some policy implications are briefly considered in the third article

A Quantitative Genetic Analysis of Cognitive Abilities During the Second Half of the Life Span

Little is known about the importance of genetic effects on individual differences in cognitive abilities late in life. We present the first report from the Swedish Adoption/Twin Study of Aging (SATSA) for cognitive data, including general cognitive ability and 13 tests of specific cognitive abilities. The adoption/twin design consists of identical twins separated at an early age and reared apart (46 pairs), identical twins reared together (67 pairs), fraternal twins reared apart (100 pairs), and fraternal twins reared together (89 pairs); average age was 65 years. Heritability of general cognitive ability in these twins was much higher (about 80%) than estimates typically found earlier in life (about 50%). Consistent with the literature, heritabilities of specific cognitive abilities were lower than the heritability of general cognitive ability but nonetheless substantial. Average heritabilities for verbal, spatial, perceptual speed, and memory tests were, respectively, 58%, 46%, 58%, and 38%