621 research outputs found
Towards a New Standard Model for Black Hole Accretion
We briefly review recent developments in black hole accretion disk theory,
emphasizing the vital role played by magnetohydrodynamic (MHD) stresses in
transporting angular momentum. The apparent universality of accretion-related
outflow phenomena is a strong indicator that large-scale MHD torques facilitate
vertical transport of angular momentum. This leads to an enhanced overall rate
of angular momentum transport and allows accretion of matter to proceed at an
interesting rate. Furthermore, we argue that when vertical transport is
important, the radial structure of the accretion disk is modified at small
radii and this affects the disk emission spectrum. We present a simple model
demonstrating how energetic, magnetically-driven outflows modify the emergent
disk emission spectrum with respect to that predicted by standard accretion
disk theory. A comparison of the predicted spectra against observations of
quasar spectral energy distributions suggests that mass accretion rates
inferred using the standard disk model may severely underestimate their true
values.Comment: To appear in the Fifth Stromlo Symposium Proceedings special issue of
ApS
Faraday rotation spectra of bismuth-substituted ferrite garnet films with in-plane magnetization
Single crystalline films of bismuth-substituted ferrite garnets have been
synthesized by the liquid phase epitaxy method where GGG substrates are dipped
into the flux. The growth parameters are controlled to obtain films with
in-plane magnetization and virtually no domain activity, which makes them
excellently suited for magnetooptic imaging. The Faraday rotation spectra were
measured across the visible range of wavelengths. To interprete the spectra we
present a simple model based on the existence of two optical transitions of
diamagnetic character, one tetrahedral and one octahedral. We find excellent
agreement between the model and our experimental results for photon energies
between 1.77 and 2.53 eV, corresponding to wavelengths between 700 and 490 nm.
It is shown that the Faraday rotation changes significantly with the amount of
substituted gallium and bismuth. Furthermore, the experimental results suggest
that the magnetooptic response changes linearly with the bismuth substitution.Comment: 15 pages, 6 figures, published in Phys. Rev.
Recent glitches detected in the Crab pulsar
From 2000 to 2010, monitoring of radio emission from the Crab pulsar at
Xinjiang Observatory detected a total of nine glitches. The occurrence of
glitches appears to be a random process as described by previous researches. A
persistent change in pulse frequency and pulse frequency derivative after each
glitch was found. There is no obvious correlation between glitch sizes and the
time since last glitch. For these glitches and
span two orders of magnitude. The pulsar suffered the
largest frequency jump ever seen on MJD 53067.1. The size of the glitch is
6.8 Hz, 3.5 times that of the glitch occured in
1989 glitch, with a very large permanent changes in frequency and pulse
frequency derivative and followed by a decay with time constant 21 days.
The braking index presents significant changes. We attribute this variation to
a varying particle wind strength which may be caused by glitch activities. We
discuss the properties of detected glitches in Crab pulsar and compare them
with glitches in the Vela pulsar.Comment: Accepted for publication in Astrophysics & Space Scienc
Reionization by active sources and its effects on the cosmic microwave background
We investigate the possible effects of reionization by active sources on the
cosmic microwave background. We concentrate on the sources themselves as the
origin of reionization, rather than early object formation, introducing an
extra period of heating motivated by the active character of the perturbations.
Using reasonable parameters, this leads to four possibilities depending on the
time and duration of the energy input: delayed last scattering, double last
scattering, shifted last scattering and total reionization. We show that these
possibilities are only very weakly constrained by the limits on spectral
distortions from the COBE FIRAS measurements. We illustrate the effects of
these reionization possibilities on the angular power spectrum of temperature
anisotropies and polarization for simple passive isocurvature models and simple
coherent sources, observing the difference between passive and active models.
Finally, we comment on the implications of this work for more realistic active
sources, such as causal white noise and topological defect models. We show for
these models that non-standard ionization histories can shift the peak in the
CMB power to larger angular scales.Comment: 21 pages LaTeX with 11 eps figures; replaced with final version
accepted for publication in Phys. Rev.
Deficiencies in the soil quality concept and its application
Soil quality is a concept that has deeply divided the soil science community. It has
been institutionalized and advocated without full consideration of concept weaknesses and
contradictions. Our paper highlights its disfunctional definition, flawed approach to
quantification, and failure to integrate simultaneous functions, which often require contradictory
soil properties and/or management. While the concept arose from a call to protect the
environment and sustain the soil resource, soil quality indexing as implemented may actually
impair some soil functions, environmental quality, or other societal priorities. We offer the
alternative view that emphasis on known principles of soil management is a better expenditure of
limited resources for soil stewardship than developing and deploying subjective indices which fail
to integrate across the necessary spectrum of management outcomes. If the soil quality concept
is retained, we suggest precisely specifying soil use, not function or capacity, as the criteria for
attribute evaluation. Emphasis should be directed toward using available technical information to
motivate and educate farmers on management practices that optimize the combined goals of high
crop production, low environmental degradation, and a sustained resource
Dimensionless cosmology
Although it is well known that any consideration of the variations of
fundamental constants should be restricted to their dimensionless combinations,
the literature on variations of the gravitational constant is entirely
dimensionful. To illustrate applications of this to cosmology, we explicitly
give a dimensionless version of the parameters of the standard cosmological
model, and describe the physics of Big Bang Neucleosynthesis and recombination
in a dimensionless manner. The issue that appears to have been missed in many
studies is that in cosmology the strength of gravity is bound up in the
cosmological equations, and the epoch at which we live is a crucial part of the
model. We argue that it is useful to consider the hypothetical situation of
communicating with another civilization (with entirely different units),
comparing only dimensionless constants, in order to decide if we live in a
Universe governed by precisely the same physical laws. In this thought
experiment, we would also have to compare epochs, which can be defined by
giving the value of any {\it one} of the evolving cosmological parameters. By
setting things up carefully in this way one can avoid inconsistent results when
considering variable constants, caused by effectively fixing more than one
parameter today. We show examples of this effect by considering microwave
background anisotropies, being careful to maintain dimensionlessness
throughout. We present Fisher matrix calculations to estimate how well the fine
structure constants for electromagnetism and gravity can be determined with
future microwave background experiments. We highlight how one can be misled by
simply adding to the usual cosmological parameter set
A Conflict Model for Strategists and Managers
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67210/2/10.1177_000276427201500604.pd
Scale-free static and dynamical correlations in melts of monodisperse and Flory-distributed homopolymers: A review of recent bond-fluctuation model studies
It has been assumed until very recently that all long-range correlations are
screened in three-dimensional melts of linear homopolymers on distances beyond
the correlation length characterizing the decay of the density
fluctuations. Summarizing simulation results obtained by means of a variant of
the bond-fluctuation model with finite monomer excluded volume interactions and
topology violating local and global Monte Carlo moves, we show that due to an
interplay of the chain connectivity and the incompressibility constraint, both
static and dynamical correlations arise on distances . These
correlations are scale-free and, surprisingly, do not depend explicitly on the
compressibility of the solution. Both monodisperse and (essentially)
Flory-distributed equilibrium polymers are considered.Comment: 60 pages, 49 figure
Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche
Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic reovirus has progressed to phase I clinical trials and its direct lytic potential has been extensively studied. However, to date, the role for reovirus-induced immunotherapy against MM, and the impact of the bone marrow (BM) niche, have not been reported.
Methods This study used human peripheral blood mononuclear cells from healthy donors and in vitro co-culture of MM cells and BM stromal cells to recapitulate the resistant BM niche. Additionally, the 5TGM1-Kalw/RijHSD immunocompetent in vivo model was used to examine reovirus efficacy and characterize reovirus-induced immune responses in the BM and spleen following intravenous administration. Collectively, these in vitro and in vivo models were used to characterize the development of innate and adaptive antimyeloma immunity following reovirus treatment.
Results Using the 5TGM1-Kalw/RijHSD immunocompetent in vivo model we have demonstrated that reovirus reduces both MM tumor burden and myeloma-induced bone disease. Furthermore, detailed immune characterization revealed that reovirus: (i) increased natural killer (NK) cell and CD8+ T cell numbers; (ii) activated NK cells and CD8+ T cells and (iii) upregulated effector-memory CD8+ T cells. Moreover, increased effector-memory CD8+ T cells correlated with decreased tumor burden. Next, we explored the potential for reovirus-induced immunotherapy using human co-culture models to mimic the myeloma-supportive BM niche. MM cells co-cultured with BM stromal cells displayed resistance to reovirus-induced oncolysis and bystander cytokine-killing but remained susceptible to killing by reovirus-activated NK cells and MM-specific cytotoxic T lymphocytes.
Conclusion These data highlight the importance of reovirus-induced immunotherapy for targeting MM cells within the BM niche and suggest that combination with agents which boost antitumor immune responses should be a priority
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