High energy shock wave induced biological effects in different tumor models

Contains fulltext : mmubn000001_143816659.pdf (publisher's version ) (Open Access)Promotores : F. Debruyne, G. Oosterhof en J. Schalken139 p

The effects of successive high-energy shock-wave tumor administration on tumor blood flow

Contains fulltext : 21301___.PDF (publisher's version ) (Open Access

In vitro proton magnetic resonance spectroscopy of four human prostate cancer cell lines

Contains fulltext : 22285___.PDF (publisher's version ) (Open Access

Influence of high intensity focused ultrasound on the development of metastases

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p16 mutations/deletions are not frequent events in prostate cancer

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Improved depth perception with three-dimensional auxiliary display and computer generated three-dimensional panoramic overviews in robot-assisted laparoscopy

In comparison to open surgery, endoscopic surgery offers impaired depth perception and narrower field-of-view. To improve depth perception, the Da Vinci robot offers three-dimensional (3-D) video on the console for the surgeon but not for assistants, although both must collaborate. We improved the shared perception of the whole surgical team by connecting live 3-D monitors to all three available Da Vinci generations, probed user experience after two years by questionnaire, and compared time measurements of a predefined complex interaction task performed with a 3-D monitor versus two-dimensional. Additionally, we investigated whether the complex mental task of reconstructing a 3-D overview from an endoscopic video can be performed by a computer and shared among users. During the study, 925 robot-assisted laparoscopic procedures were performed in three hospitals, including prostatectomies, cystectomies, and nephrectomies. Thirty-one users participated in our questionnaire. Eighty-four percent preferred 3-D monitors and 100% reported spatial-perception improvement. All participating urologists indicated quicker performance of tasks requiring delicate collaboration (e.g., clip placement) when assistants used 3-D monitors. Eighteen users participated in a timing experiment during a delicate cooperation task in vitro. Teamwork was significantly (40%) faster with the 3-D monitor. Computer-generated 3-D reconstructions from recordings offered very wide interactive panoramas with educational value, although the present embodiment is vulnerable to movement artifacts. © 2014 Society of Photo-Optical Instrumentation Engineers (SPIE